Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α
By M. Moss, S. Jin, M. Milla, W. Burkhart, H. Carter, Wenjing Chen, W. C. Clay, J. Didsbury, Daniel F. Hassler, C. Hoffman and 16 more. 1997
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Citations in the corpus
- TNF and MAP kinase signaling pathways (2014, unknown): “ERK and TNFα shedding—ERK1/2 have been proposed to promote the processing of pro-TNFα by phosphorylation of TNFα converting enzyme (TACE) [84], the protease that cleaves pro-TNFα to release secreted TNFα [85].”
- The Cysteine-Rich Domain of Human Adam 12 Supports Cell Adhesion through Syndecans and Triggers Signaling Events That Lead to β1 Integrin–Dependent Cell Spreading (2000, background): “A well-studied example is ADAM 17 (TACE), which functions in cell surface shedding of a number of growth factors, including tumor necrosis factora (TNF a ), transforming growth factora (TGF a ), and Notch (Black et al., 1997; Moss et al., 1997; Peschon et al., 1998; Brou et al., 2000).”
- Cytokines in atherosclerosis: pathogenic and regulatory pathways. (2006, background): “However, even if ADAM17 is the main modulator of the generation of TNF- activity, MMP1 and MMP-9 are able to cleave proTNF even though they do not produce active TNF- (477).”
- Phenotypic Analysis of Meltrin α (ADAM12)-Deficient Mice: Involvement of Meltrin α in Adipogenesis and Myogenesis (2003, background): “For example, TACE (ADAM17) was initially identified as the protease responsible for the processing of tumor necrosis factor alpha (2, 23).”
- Metalloprotease-Disintegrins: Links to Cell Adhesion and Cleavage of TNFα and Notch (1997, methodology): “Both Moss et al. (1997) tokines such as the kit-ligand, TGFa, Fas-ligand, cytokine receptors such as the IL-6 receptor and the NGFand Black et al. (1997) used a peptide cleavage assay and a TNFa conversion assay to monitor purification of receptor, as well as adhesion proteins such as L-selectin,…”