TNF and MAP kinase signaling pathways

By G. Sabio, R. Davis. Seminars in Immunology, 2014

663 citations recorded by the source corpus.

The binding of tumor necrosis factor α (TNFα) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: extracellular-signal-regulated kinases (ERKs); the cJun NH2-terminal kinases (JNKs); and the p38 MAP kinases. These MAP kinase signalling pathways induce a secondary response by increasing the expression of several inflammatory cytokines (including TNFα) that contribute to the biological activity of TNFα. MAP kinases therefore function both upstream and down-stream of signalling by TNFα receptors. Here we review mechanisms that mediate these actions of MAP kinases during the response to TNFα.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/0825d72e39bd64f48faf85c465f3ca1248430206

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Citations in the corpus

• ERK/MAPK signalling pathway and tumorigenesis (2020, background): “Therefore, MAPK cascades are central signalling elements that regulate basic processes including cell proliferation, differentiation and stress responses (1-3).”