GPCRdb: an information system for G protein-coupled receptors

By Vignir Ísberg, Stefan Mordalski, Christian Munk, Krzysztof Rataj, Kasper Harpsøe, Alexander Sebastian Hauser, B. Vroling, Andrzej J. Bojarski, G. Vriend, David E. Gloriam. 2015

377 citations recorded by the source corpus.

Recent developments in G protein-coupled receptor (GPCR) structural biology and pharmacology have greatly enhanced our knowledge of receptor structure-function relations, and have helped improve the scientific foundation for drug design studies. The GPCR database, GPCRdb, serves a dual role in disseminating and enabling new scientific developments by providing reference data, analysis tools and interactive diagrams. This paper highlights new features in the fifth major GPCRdb release: (i) GPCR crystal structure browsing, superposition and display of ligand interactions; (ii) direct deposition by users of point mutations and their effects on ligand binding; (iii) refined snake and helix box residue diagram looks; and (iii) phylogenetic trees with receptor classification colour schemes. Under the hood, the entire GPCRdb front- and back-ends have been re-coded within one infrastructure, ensuring a smooth browsing experience and development. GPCRdb is available at http://www.gpcrdb.org/ and it's open source code at https://bitbucket.org/gpcr/protwis.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

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Citations in the corpus

GPCRdb in 2023: state-specific structure models using AlphaFold2 and new ligand resources (2022, background): “Given that this is our fifth publication of a major GPCRdb release (18,19,23,24), and additional resources have published (14,25) after the latest publication (19), we provide an overview of the current data, analysis, data-driven experiment design, and data deposition in Figures 1 and 2.”
The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands (2015, background): “The expansion of our interactions with GPCRDB during 2014 / 15 exemplifies this, since both resources have had historically overlapping engagement with the human GPCR repertoire (29,30).”