Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance

By A. Limmer, J. Ohl, C. Kurts, H. Ljunggren, Y. Reiss, M. Groettrup, F. Momburg, B. Arnold, P. Knolle. Nature Medicine, 2000

786 citations recorded by the source corpus.

Subfields: Immunology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. (2011, background): “…al., 2008). pDCs constitute a substantial fraction of antigen-presenting cells (APC) in the liver and, along with nonhematopoietic endothelial cells (Limmer et al., 2000) and hepatic stellate cells (Winau et al., 2007), might present intestinal antigens in the liver to induce intestinal tolerance.”
Liver sinusoidal endothelial cells: Physiology and role in liver diseases. (2017, background): “by LSECs leads to tolerance induction in CD8+ cells [133].”
Cross‐presentation, dendritic cell subsets, and the generation of immunity to cellular antigens (2004, background): “Several other cell types have been reported to cross-present, including B cells (15), endothelial cells (16, 17), and particularly macrophages (18–22), the latter of which have in some cases been compared to DCs (22).”
The Linkage of Innate to Adaptive Immunity via Maturing Dendritic Cells In Vivo Requires CD40 Ligation in Addition to Antigen Presentation and CD80/86 Costimulation (2004, background): “First, we verified the need for bone marrow–derived cells in the presentation of cell-associated protein because it has been reported that nonhematopoietic, liver sinusoidal endothelial cells were also able to present OVA on MHC class I by a TAP-dependent pathway (39).”