Reward learning in normal and mutant Drosophila.

By Bruce L. Tempel, N. M. Bonini, D. Dawson, William G. Quinn. 1983

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Citations in the corpus

Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila (2015, positive): “The ends of the steel electrode leads were connected to a stimulator (Grass Technologies), which was used to apply a 500 ms pulse of 60-150V, comparable to the electrical shock parameters used in classical olfactory conditioning paradigms (Tempel et al., 1983; Tully and Quinn, 1985).”
Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, methodology): “…and odor-sugar associative memory We asked which MBONs were required for aversive and appetitive odor memory, using a wellestablished discriminative olfactory learning paradigm (Figure 6A) (Tempel et al., 1983; Tully and Quinn, 1985; Schwaerzel et al., 2003; Gerber et al., 2004; Davis, 2005).”
The neuronal architecture of the mushroom body provides a logic for associative learning (2014, background): “In associative olfactory learning, exposure to an odor (conditioned stimulus, CS) in association with an unconditioned stimulus (US) results in appetitive or aversive memory (Quinn et al., 1974; Tempel et al., 1983; Tully and Quinn, 1985).”
Dopamine Is Required for Learning and Forgetting in Drosophila (2012, neutral): “days (Tempel et al., 1983; Krashes andWaddell, 2008).”
Dopamine and Octopamine Differentiate between Aversive and Appetitive Olfactory Memories in Drosophila (2003, methodology): “, 1985), and depend on cAMP signaling as revealed by the impairment in mutants such as dunce, rutabaga (rut), and amnesiac (amn) affecting different steps in cAMP metabolism (Tempel et al., 1983).”
Rapid Consolidation to a radish and Protein Synthesis-Dependent Long-Term Memory after Single-Session Appetitive Olfactory Conditioning in Drosophila (2008, methodology): “Two reports of appetitive conditioning in Drosophila using a two-trial massed procedure observed measurable levels of memory up to 24 h after training (Tempel et al., 1983; Schwaerzel et al., 2007), and we previously determined that flies trained with a 2 min odor exposure paired with sucrose reveal”
Do the right thing: neural network mechanisms of memory formation, expression and update in Drosophila (2018, background): “If the odor is later presented without reward, learned behavior is extinguished — the previously learned odor is no longer approached in a test situation [9 ,41].”
Flies, genes, and learning. (2001, background): “Training to sugar reward appears to elicit longer memories than equivalent training to electric shock punishment, with surprising linear additivity of behavioral performance following the two reinforcements (Tempel et al 1983).”
Pain-relief learning in flies, rats, and man: basic research and applied perspectives (2014, background): “to such punishment-learning, an appetitive version of the paradigm is available which uses sugar as reward (Tempel et al. 1983): When flies receive an odor together with a sugar reward,”
Neuronal mechanisms underlying innate and learned olfactory processing in Drosophila. (2019, background): “, odor+food LTM arises from a 285 single pairing, whereas odor+shock LTM requires multiple spaced training trials) [88-90].”
Dynamics of learning-related cAMP signaling and stimulus integration in the Drosophila olfactory pathway. (2009, unknown): “Since cAMP signaling is critical for performance in both appetitive and aversive conditioning paradigms (Tempel et al., 1983), the intracellular signaling cascades are likely similar in both types of learning.”
Genetic dissection of consolidated memory in Drosophila. (1994, background): “Both learning and early memory are disrupted in dunce and rutabaga mutants (Tempel et al., 1983; Dudai, 1983; Tully and Quinn, 1985) but some ARM nevertheless is apparent (Tully and Quinn, 1985; Dudai et al.”
A pair of inhibitory neurons are required to sustain labile memory in the Drosophila mushroom body (2011, unknown): “Fruit flies form robust aversive or appetitive olfactory memory following a training session pairing odorant exposure with electric shock punishment or sucrose reward, respectively [12, 13].”
Spaced Training Forms Complementary Long-Term Memories of Opposite Valence in Drosophila (2019, unknown): “When differentially conditioned by pairing one odor with shock and the other with sugar flies show additive initial performance to that observed if only one of the two odors had been reinforced (Tempel et al., 1983).”
System-like consolidation of olfactory memories in Drosophila (2013, methodology): “For aversive and appetitive training, flies were conditioned behaviorally using a standard, two-odor discriminative and negatively or positively reinforced classical-conditioning paradigm (Tempel et al., 1983; Tully and Quinn, 1985).”
Different Kenyon Cell Populations Drive Learned Approach and Avoidance in Drosophila (2013, unknown): “…g in short-term memory, for a0b0 after training for memory consolidation, and for ab in later memory retrieval, with the ab requirement becoming more pro- nounced as time passes (Zars et al., 2000; Yu et al., 2006; Krashes et al., 2007; Blum et al., 2009; Trannoy et al., 2011; Qin et al., 2012).”
Short Neuropeptide F Acts as a Functional Neuromodulator for Olfactory Memory in Kenyon Cells of Drosophila Mushroom Bodies (2013, methodology): “Mixed populations of 2- to 6-d-old males and females were trained and tested for 2 h appetitive olfactory memory as previously described (Tempel et al., 1983; Thum et al., 2007).”
A Normative Theory of Forgetting: Lessons from the Fruit Fly (2014, background): “aversive conditioning is forgotten approximately twice as quickly as appetitive conditioning [10,11].”