Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone
By E. Horwitz, P. L. Gordon, W. K. Koo, J. Marx, M. Neel, R. Mcnall, L. Muul, T. Hofmann. Proceedings of the National Academy of Sciences of the United States of America, 2002
1,730 citations recorded by the source corpus.
Subfields: Epidemiology, Genetics
View Paper: https://www.semanticscholar.org/paper/5c7389dbb42fe49bee767a03d389aefb139c3149
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Citations in the corpus
- Why are MSCs therapeutic? New data: new insight (2009, background): “A clear example of these efforts is documented in the publications of Horwitz and colleagues, in which they describe their attempts to cure osteogenesis imperfecta (OI) by allogeneic bone marrow transplantation, including a ‘booster’ shot of MSCs intravenously 18 months after the original allogeneic”
- Clinical Trials with Mesenchymal Stem Cells: An Update (2016, background): “authors confirmed these promising results by increasing the number of children treated with an MSC population isolated and purified from BM (50,52).”
- HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. (2003, background): “Human MSC can also engraft in bone after intravenous infusion and improve body length and bone mineralization in patients with osteogenesis imperfecta [26].”
- Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy (2004, background): “MSCs are considered a readily accepted source of stem cells because such cells have already demonstrated efficacy in multiple types of cellular therapeutic strategies, including applications in treating children with osteogenesis imperfecta [1], hematopoietic recovery [2], and bone tissue regenerati”
- Mechanisms of mesenchymal stem/stromal cell function (2016, background): “These observations sparked a substantial degree of interest in the potential application of MSCs for the repair of serious connective tissue trauma and disease [6–10].”
- Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone (2008, background): “Although multipotent mesenchymal stromal cells (MSCs, also termed 'mesenchymal stem cells') hold the potential for curing generalized skeletal diseases, their clinical effectiveness is constrained by the poor osteotropism of infused MSCs (refs”