Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines.

By Joseph D. Miller, R. G. van der Most, Rama S. Akondy, John Glidewell, Sophia Albott, D. Masopust, Kaja Murali-Krishna, Patryce L. Mahar, S. Edupuganti, S. Lalor and 7 more. Immunity, 2008

625 citations recorded by the source corpus.

Subfields: Infectious Diseases, Molecular Biology, Virology

View Paper: https://www.semanticscholar.org/paper/5c0fc07eabaef12a19f4c5c67988eda647695110

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In Infectious Diseases

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Citations in the corpus

• Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1–targeted therapy in lung cancer patients (2017, background): “Several markers can be used to identify effector T cells that expand during immune responses— for example, yellow fever virus-specific effector CD8 T cells induced by vaccination are human leukocyte antigen–antigen D-related positive (HLA-DR+) CD38+ Ki-67+ Bcl-2 (16, 17) (Fig.”
• Predicting evolution (2017, background): “At the peak of an acute infection, a substantial fraction of the functional immune receptors responds to specific antigens 22,45 .”
• Human T cell development, localization, and function throughout life (2018, background): “…show activated CD4+ and CD8+T cells co-expressing CD38 and HLA-DR detectable in the blood within 2–3 days; YFV-specific CD8+ T cells are subsequently detectable in blood and exhibit peak responses after 14–21 days (Akondy et al., 2015; Blom et al., 2013; Miller et al., 2008; Wieten et al., 2016a).”
• Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans (2008, background): “During the response to vaccination with YF-17D, activated CD8 + T cells transiently upregulate HLA-DR, CD38 and Ki-67 (a protein expressed during the cell cycle) and downregulate the antiapoptotic protein Bcl-2, and that the peak of expansion occurs at 2 week”
• Rescue of exhausted CD8 T cells by PD-1 targeted therapies is CD28-dependent (2017, background): “Human effector CD8 T cells induced by vaccination have been identified by HLADR, CD38 and Ki-67 expression (16).”
• Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients. (2011, result): “In contrast to vaccines consisting of synthetic molecules and inactivated pathogens, live vaccines (essentially vaccinia virus and yellow fever vaccine) can induce high T cell frequencies (42, 43) and efficient protection.”