PTEN: life as a tumor suppressor.

By Laura Simpson, R. Parsons. Experimental Cell Research, 2001

700 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/5be52f78cc9e1fc41dec2cfc900f1cb96a8e8974

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. H. Ohgaki
2. P. Kleihues
3. N. Hay
4. Nahum Sonenberg
5. T. Mak
6. Arnold J. Levine
7. C. Heinlein
8. Chawnshang Chang

In Physiology

1. N. Hay
2. Nahum Sonenberg
3. T. Mak

Citations in the corpus

• Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. (2001, background): “…as a result of mutation/deletion of the tumor suppressor PTEN, a phospholipid phosphatase that negatively regulates Akt activation (for review, see Simpson and Parsons 2001), amplification of the catalytic subunit of PI 3-kinase (Shayesteh et al. 1999), amplification of the akt genes (Staal 1987;…”
• Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. (2005, background): “The PTEN gene encodes a protein that plays important roles in the regulation of cell proliferation, apoptosis, and tumor invasion (31, 32).”
• Upstream and downstream of mTOR. (2004, background): “For instance, loss-of-function mutations of the tumor suppressor PTEN in human cancers occur with a frequency nearly that of the tumor suppressor p53 (Cantley and Neel 1999; Simpson and Parsons 2001).”
• Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. (2003, background): “The transcriptional activity of C/EBP and C/EBP is dependent, to some extent, on the down-regulation of CHOP10 upon induction of differentiation.”
• Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis (2006, background): “gov/cancertopics/types/lung">lung and colon cancers, they are rarely found in glioblastomas; the opposite is true for PTEN mutation”
• Genetic Pathways to Glioblastoma (2004, background): “PTEN gene locates on chromosome 10q23 and encodes a protein that plays important roles in the regulation of cell proliferation, apoptosis, and tumor invasion (41, 42).”