Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism.

By T. Shimada, M. Kakitani, Y. Yamazaki, H. Hasegawa, Y. Takeuchi, T. Fujita, S. Fukumoto, K. Tomizuka, T. Yamashita. Journal of Clinical Investigation, 2004

1,485 citations recorded by the source corpus.

Subfields: Genetics, Nephrology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/5b8bf270a1baf16731c29c7fa998d706f36ca7fe

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. M. Mohammadi
2. N. Itoh
3. A. Beenken
4. D. Ornitz
5. M. Kuro-o

In Nephrology

1. M. Mohammadi
2. A. Beenken

Citations in the corpus

• The FGF family: biology, pathophysiology and therapy (2009, positive): “Abnormalities of phosphate metabolism and bone mineral density in Kl −/− mice were similar to those observed in Fgf23 knockout mic”
• Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease. (2005, background): “In contrast, FGF-23 gene-ablated mice develop hyperphosphatemia and excessive calcitriol levels (29,35).”
• Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. (2011, background): “ually die, usually by 12 weeks of age (26).”
• Vitamin D and human health: lessons from vitamin D receptor null mice. (2008, background): “These data indicate that alterations in mineral metabolism in FGF23 null mice require an intact 1,25- (OH)2D-VDR signaling pathway.”
• Fibroblast growth factor 23 (FGF23) predicts progression of chronic kidney disease: the Mild to Moderate Kidney Disease (MMKD) Study. (2007, neutral): “13 Current smokers (n % ) 18 (16) 16 (25) 0.”
• Regulation of Phosphate Homeostasis by PTH, Vitamin D, and FGF23 (2010, background): “Liu S, Zhou J, Tang W, et al. Pathogenic role of Fgf23 in Dmp1-null mice.”
• Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. (2010, background): “FGF23 is secreted from the bone to regulate phosphate and calcium homeostasis (69, 70).”