Sleep and Alzheimer disease pathology—a bidirectional relationship

By Yo-El S Ju, B. Lucey, D. Holtzman. Nature Reviews Neurology, 2013

915 citations recorded by the source corpus.

Factors other than age and genetics may increase the risk of developing Alzheimer disease (AD). Accumulation of the amyloid-β (Aβ) peptide in the brain seems to initiate a cascade of key events in the pathogenesis of AD. Moreover, evidence is emerging that the sleep–wake cycle directly influences levels of Aβ in the brain. In experimental models, sleep deprivation increases the concentration of soluble Aβ and results in chronic accumulation of Aβ, whereas sleep extension has the opposite effect. Furthermore, once Aβ accumulates, increased wakefulness and altered sleep patterns develop. Individuals with early Aβ deposition who still have normal cognitive function report sleep abnormalities, as do individuals with very mild dementia due to AD. Thus, sleep and neurodegenerative disease may influence each other in many ways that have important implications for the diagnosis and treatment of AD.

Subfields: Cognitive Neuroscience, Experimental and Cognitive Psychology, Physiology

View Paper: https://www.semanticscholar.org/paper/5b79f0b63e8b84d3f02f5bfbf28804aaf9c6c93e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

In Experimental and Cognitive Psychology

In Physiology

Citations in the corpus

β-Amyloid accumulation in the human brain after one night of sleep deprivation (2018, background): “This association has been considered bidirectional because increased ABB could also lead to impairments in sleep (9, 10).”
Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population‐based perspective (2015, neutral): “Several cohort and observational studies link sleep disturbances (for example, insomnia and sleep apnea) to increased risk for cognitive decline [129–137].”
An open-source, high-performance tool for automated sleep staging (2021, background): “…strategy to reduce the risk of cardio-vascular and metabolic disease, all-cause mortality risk, and more recently, the accumulation of Alzheimer’s disease pathology within the brain ( Cappuccio et al., 2010 ; Leary et al., 2020Cappuccio and Miller, 2017 ; Ju et al., 2014 ; Winer et al., 2020 ).”
Understanding the impact of sex and gender in Alzheimer's disease: A call to action (2018, background): “Sleep Sleep and circadian rhythms disturbances are common among patients with AD and may impact the development of AD pathology as well [33].”