Paradoxical influence of hippocampal neurogenesis on working memory

By M. Saxe, G. Malleret, Svetlana Vronskaya, Indira Mendez, A. Garcia, M. Sofroniew, E. Kandel, R. Hen. 2007

259 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience

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Citations in the corpus

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “Indeed, mice in which neurogenesis was suppressed by two independent approaches performed better than controls in a spatial working memory task in an eight-arm radial maze with high interference (for example, the sample arms and/or goal arm being used repeatedly and interchangeably) and long delays ”
Impaired Adult Neurogenesis Associated with Short-Term Memory Defects in NF-κB p50-Deficient Mice (2008, background): “Several groups have reported data correlating alterations in neurogenesis with deficit/enhancement in learning and memory performance (Gould et al., 1999; van Praag et al., 1999; Shors et al., 2001; Kempermann, 2002; Aimone et al., 2006; Leuner et al., 2006; Kee et al., 2007; Saxe et al., 2007).”
Adult-Generated Hippocampal Neurons Allow the Flexible Use of Spatially Precise Learning Strategies (2009, result): “This might at least partly explain the somewhat contradictory results of previous studies using the DMP version of the MWM paradigm without assessing the qualitative aspects of spatial learning [27,28] (but see also [7]).”
Adult neurogenesis and the olfactory system. (2009, background): “Ablating neurogenesis impairs spatial memory and contextual fear conditioning (Saxe et al., 2006; Imayoshi et al., 2008), but actually improved performance on some working memory tasks (Saxe et al., 2007).”
Adult-born hippocampal neurons are more numerous, faster-maturing and more involved in behavior in rats than in mice (2009, background): “much longer than in rat studies (Saxe et al., 2006; Saxe et al., 2007; Imayoshi et al., 2008).”
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. (2009, background): “This manipulation led to a substantial reduction of neurogenesis after Ganciclovir injection (Garcia et al. 2004; Saxe et al. 2006, 2007 ).”
The Timing of Differentiation of Adult Hippocampal Neurons Is Crucial for Spatial Memory (2008, background): “toxin, x-ray irradiation, or virus-activated pro-drugs results in profound cognitive deficits [24–28].”
Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation (2011, methodology): “…tasks, animals were trained to learn one pattern and were subsequently tested, using a working memory framework, for their ability to discriminate a learned pattern from another pattern (Clelland et al., 2009; Creer et al., 2010; Gilbert et al., 2001; Hunsaker and Kesner, 2008; Saxe et al., 2007).”
Structural Plasticity and Hippocampal Function (2010, background): “…of newly generated cells in hippocampaldependent learning (Hernandez-Rabaza et al. 2009, Jessberger et al. 2009, Shors et al. 2002, Snyder et al. 2005, Zhang et al. 2008), and there is at least one demonstration of enhanced learning following the suppression of neurogenesis (Saxe et al. 2007).”
Computational influence of adult neurogenesis on memory encoding. (2009, unknown): “Of the previous behavioral results using knockdownmodels of neurogenesis, perhaps the most relevant to our model is the observation that irradiated animals have improved performance on a working memory (Saxe et al., 2007).”
Mechanisms and functional implications of adult neurogenesis. (2008, unknown): “Intriguingly, ablation of hippocampal neurogenesis even caused an improvement in hippocampus-dependent working memory in the eight-armed radial maze (Saxe et al., 2007), suggesting that adult-born neurons may have distinct roles in the formation of different types of memories.”
Anatomical gradients of adult neurogenesis and activity: young neurons in the ventral dentate gyrus are activated by water maze training (2009, unknown): “…functional (Wang et al., 2000; Snyder et al., 2001; van Praag et al., 2002; Esposito et al., 2005; Ge et al., 2006) and contribute to hippocampus-dependent behaviors (Shors et al., 2001, 2002; Santarelli et al., 2003; Snyder et al., 2005; Saxe et al., 2006, 2007; Winocur et al., 2006).”