Control Mechanism of the Circadian Clock for Timing of Cell Division in Vivo

By Takuya Matsuo, S. Yamaguchi, S. Mitsui, A. Emi, F. Shimoda, H. Okamura. Science, 2003

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The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease (2008, background): “For example, in regenerating liver following partial hepatectomy in mice, Okamura and colleagues have shown that the circadian clock system controls cell-cycle related genes that modulate the activity of cyclin B1–CDC2 kinase, a key mitotic regulato”
The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. (2006, background): “The significance of proper circadian regulation to cell cycle progression and the DNA damage response was recently demonstrated by studies in Cry and Per2 mutant mice showing improper cell division and increased sensitivity to radiation (Fu et al., 2002; Matsuo et al., 2003).”
Liver regeneration: from myth to mechanism (2004, background): “Moreover, circadian rhythms might affect the timing of DNA synthesis and the expression of cyclins after partial hepatectom”
BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis (2004, background): “…that link them to the SCN remain largely obscure, genetic mutation or deletion has implicated peripheral clocks in the regulation of some aspects of cellular function, including division (Matsuo et al. 2003), estrous cyclicity (Miller et al. 2004), and phospholipid metabolism (Marquez et al. 2004).”