Conformational diversity and protein evolution--a 60-year-old hypothesis revisited.

By L. James, Dan S. Tawfik. 2003

531 citations recorded by the source corpus.

Subfields: Materials Chemistry, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Materials Chemistry

1. Gaetano T. Montelione
2. David Baker
3. Ruth Nussinov
4. Gaohua Liu
5. O. Khersonsky
6. John Karanicolas
7. Dan S. Tawfik
8. J. Corn

In Molecular Biology

1. David Baker
2. Gaetano T. Montelione
3. John Karanicolas
4. O. Khersonsky
5. Dan S. Tawfik
6. Ruth Nussinov
7. Gaohua Liu
8. I. Samish

Citations in the corpus

• Enzyme promiscuity: evolutionary and mechanistic aspects. (2006, background): “The article demonstrates how conformational diversity can mediate functional diversity (for a review of this concept see [17]).”
• Latent evolutionary potentials under the neutral mutational drift of an enzyme (2007, background): “In doing so, proteins and RNA may adopt alternative conformations that differ from the conformation that mediates their primary function (James and Tawfik, 2003; Ma et al., 2002; Schultes and Bartel, 2000).”
• Turning a hobby into a job: How duplicated genes find new functions (2008, background): “, and the tendency for proteins to have minor functions, or even functions unrelated to their evolved roles, is surprisingly commo”
• A de novo protein binding pair by computational design and directed evolution (2011, background): “The Orientational Specificity of Protein Complexes In vitro evolved proteins are frequently found to be promiscuous, exhibiting a wide range of crossreactivity (Aharoni et al., 2005; Bridgham et al., 2006; Collins et al., 2006; James and Tawfik, 2003; Khersonsky et al., 2006).”
• A structural model of latent evolutionary potentials underlying neutral networks in proteins (2007, background): “Promiscuity (polyreactivity) in function can be underlied by dynamic interconversions among energetically similar structures of a protein (James and Tawfik, 2003).”
• Antibody Polyreactivity in Health and Disease: Statu Variabilis (2013, background): “This model, in contrast to the induced-fit binding model, stipulates that an Ab molecule exists as equilibrium between its different structural variants (33, 37) (Fig.”
• Enzyme promiscuity: a mechanistic and evolutionary perspective. (2010, background): “They are typically located on sur- faceloopsthatexhibithighconformationalflex-ibility of the active site (66, 67, 138, 144, 145).”
• The role of dynamic conformational ensembles in biomolecular recognition (2009, background): “, thus protein conformational diversity and functional promiscuity are closely connected and are a potential means of molecular evolutio”
• Sequence-similar, structure-dissimilar protein pairs in the PDB (2007, background): “For example, there are over 2600 (11,700) pairs with sequence identity greater or equal to 50% and RMSDs 6 Å ( 3 Å).”