Statins and the risk of colorectal cancer.

By H. Welch. New England Journal of Medicine, 2005

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Statins and cancer prevention (2005, background): “Using statins for at least 5 years was associated with a significant (47%) reduction in the risk for developing colorectal cancer after adjustments for multiple factors, including ethnicity, family history, NSAID use and hypercholesterolaemi”
Interpretation of the evidence for the efficacy and safety of statin therapy. (2016, result): “lower rate of cancer-related mortality after adjustment for the potential confounding factors that had been recorded(90) and, in some other observational studies,(136) with as much as a halving in colon cancer incidence and in prostate cancer mortality.(137,138) By contrast, there were small excesse”
Anti-Inflammatory Effects of Statins: Clinical Evidence and Basic Mechanisms (2005, background): “For example, inflammation contributes to the development of a number of malignancies and emerging observations suggest that statins might reduce the relative risk of colorectal cance”
The Hippo Signaling Pathway in Development and Disease (2019, background): “Anecdotally, statin use was associated with a 47 percent reduction in the risk of colorectal cancer (Poynter et al., 2005), although it remains unclear whether any part of this effect is mediated by YAP inhibition.”