Phenolics metabolism and lignin synthesis in root suspension cultures of Panax ginseng in response to copper stress

By M. Ali, Nisha Singh, A. M. Shohael, E. Hahn, Kee Yoeup Paek. 2006

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Cell Wall Metabolism in Response to Abiotic Stress (2015, background): “This was correlated with an accumulation of lignin, indicating a protective response to higher levels of Cu [259].”
Exploring plant tissue culture to improve the production of phenolic compounds: A review (2016, methodology): “Copper was used to enhance the production of phenolic compounds in root culture of Panax ginseng, increasing up to 76% the production of phenolics and flavonoids (Ali et al., 2006). Similar results were found in cell culture of V. vinifera cv. Gamay Red, where the application of magnesium to the cul”
Antioxidants and Antioxidant Enzymes in Higher Plants (2018, background): “Moreover, the excess Cu2+ ions were reported to induce the biosynthesisof flavonoids (mostly luteolin glycosides) in the absence of UV irradiance (Ali et al. 2006).”
Transcriptional and physiological analyses identify a regulatory role for hydrogen peroxide in the lignin biosynthesis of copper-stressed rice roots (2014, background): “Heavy metals, including Cu, cadmium (Cd), and manganese (Mn), may affect lignin biosynthesis, which in some cases leads to increases in tissue lignin content (Diaz et al. 2001; Chen et al. 2002; Ederli et al. 2004; Lin et al. 2005; Ali et al. 2006; Yang et al. 2007; Kováčik and Klejdus 2008; Lequeux”