Circadian rhythms: mechanisms and therapeutic implications.

By Francis Levi, U. Schibler. Annual Review of Pharmacology and Toxicology, 2007

673 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Experimental and Cognitive Psychology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/59ede504bf0a153bb41ce7659c9b787dc67831d9

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In Endocrine and Autonomic Systems

In Experimental and Cognitive Psychology

In Molecular Biology

Citations in the corpus

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation (2018, background): “In mammals, including humans, the circadian system is organized into a hierarchical manner with a central pacemaker in the suprachiasmatic nucleus (SCN) of the brain’s hypothalamus (Levi and Schibler, 2007).”
Physiology of circadian entrainment. (2010, background): “, the time-specific treatment of pathological symptoms, appears to be very relevant for therapeutics, not only in terms of chronopharmacology but also for ensuring the correct entrainment of rhythms to their environment and a synchronized internal temporal order (276).”
JTK_CYCLE: an efficient non-parametric algorithm for detecting rhythmic components in genome-scale datasets (2010, background): “Most significant, disruptions of circadian rhythms have been linked to a variety of pathologies in humans, including cancer, increased susceptibility to heart disease, metabolic disorders, and some mental illnesses (Curtis and Fitzgerald, 2006; Klerman, 2005; Levi and Schibler, 2007; Paschos et al.,”
A circadian gene expression atlas in mammals: Implications for biology and medicine (2014, methodology): “At its core, this field aims to understand how time of day influences the metabolism, efficacy, toxicity, and off-target effects of therapeutics (1).”
Harmonics of Circadian Gene Transcription in Mammals (2009, background): “metabolic and cardiovascular disorders, cancer, and aging [3–5].”
Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes (2009, background): “, 2006) and contribute to the dosing time-dependence of drug activity and toxicity (Levi and Schibler, 2007).”
The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease (2008, background): “Such desynchrony with the external world and the consequential internal desynchrony of the circadian system can contribute significantly to the morbidity and the well-being of human healt”