Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer
By M. Dominguez-Bello, Kassandra M. De Jesús-Laboy, N. Shen, Laura M. Cox, Amnon Amir, Antonio Gonzalez, Nicholas A. Bokulich, S. Song, Marina Hoashi, J. Rivera-Viñas and 3 more. Nature Medicine, 2016
859 citations recorded by the source corpus.
Exposure of newborns to the maternal vaginal microbiota is interrupted with cesarean birthing. Babies delivered by cesarean section (C-section) acquire a microbiota that differs from that of vaginally delivered infants, and C-section delivery has been associated with increased risk for immune and metabolic disorders. Here we conducted a pilot study in which infants delivered by C-section were exposed to maternal vaginal fluids at birth. Similarly to vaginally delivered babies, the gut, oral and skin bacterial communities of these newborns during the first 30 d of life was enriched in vaginal bacteria—which were underrepresented in unexposed C-section–delivered infants—and the microbiome similarity to those of vaginally delivered infants was greater in oral and skin samples than in anal samples. Although the long-term health consequences of restoring the microbiota of C-section–delivered infants remain unclear, our results demonstrate that vaginal microbes can be partially restored at birth in C-section–delivered babies.
Subfields: Epidemiology, Molecular Biology, Rheumatology
View Paper: https://www.semanticscholar.org/paper/59dc4245fcc90aa037934decdc694b5fc6534701
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Citations in the corpus
- The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota (2017, result): “Recent results suggest that the fecal, skin, and oral microbiotas of the exposed neonates more closely resemble those from vaginally born than from caesarean section-born babies (524).”
- The Central Nervous System and the Gut Microbiome (2016, background): “However, some restoration towards vaginal-derived microbial status can be achieved by exposing newborns to vaginal microorganisms derived from their mothers (Dominguez-Bello et al., 2016).”
- The gut microbiome: Relationships with disease and opportunities for therapy (2018, background): “In a recent proof-of-principle study, the gut microbiota of cesarean section–delivered infants was manipulated to more closely resemble that of vaginally delivered newborns by swabbing the neonate with gauze inoculated with the mother’s vaginal microbiota (Dominguez-Bello et al., 2016).”
- Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations (2018, background): “Early successes with therapeutic microbiota transplantation further indicates the importance of these populations 175,176 .”
- Maturation of the Infant Microbiome Community Structure and Function Across Multiple Body Sites and in Relation to Mode of Delivery (2017, neutral): “Since other studies have not reported maternal gestational nor Type II diabetes as characteristics of their cohort, we cannot directly compare nor speculate as to whether their findings might be a result of confounding or co-linearity 24,40,42–44 , 52 .”
- A critical assessment of the “sterile womb” and “in utero colonization” hypotheses: implications for research on the pioneer infant microbiome (2017, background): “Several studies have reported significant differences in the diversity and composition between vaginally versus C-section-delivered infants [101, 105, 106, 108], with vaginally born infants harboring an early microbiome that resemble that of the vagina, while the microbiomes of C-section infants ref”
- Antibiotic-Induced Changes in the Intestinal Microbiota and Disease. (2016, background): “Notably, swabbing newborns delivered by C-section with gauze incubated in the vagina has been shown to partially restore a normal microbiota, albeit with effects that remain to be ascertained [86].”