A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane.

By Jörg König, Yunhai Cui, A. Nies, D. Keppler. American Journal of Physiology - Gastrointestinal and Liver Physiology, 2000

641 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Epidemiology, Oncology

View Paper: https://www.semanticscholar.org/paper/59ad0cd0e939abdeacc0dbc5298bff806c7f2da3

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In Clinical Biochemistry

1. M. Niemi
2. P. Meier
3. B. Hagenbuch
4. H. Jaeschke
5. A. Kalliokoski

In Epidemiology

1. Steven Dooley
2. M. Niemi
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5. M. Roth
6. A. Obaidat
7. A. Kalliokoski
8. P. Meier

Citations in the corpus

• Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation (2010, background): “…membrane of hepatocytes (Oatp1a1, -1a4, -1b2 and OATP1B1, -1B3, -2B1), although human OATP1A2 is localized to the apical surface of cholangiocytes (Bergwerk et al., 1996; Kakyo et al., 1999; Reichel et al., 1999; König et al., 2000a,b; Cattori et al., 2001; Lee et al., 2005a; Grube et al., 2006a).”
• Impact of OATP transporters on pharmacokinetics (2009, methodology): “OATP1B1 (previously known as OATP2, OATP-C and LST-1) is mainly expressed on the sinusoidal membrane of human hepatocytes (Abe et al., 1999; Hsiang et al., 1999; König et al. 2000a).”
• Organic Anion Transporting Polypeptide 1B1: a Genetically Polymorphic Transporter of Major Importance for Hepatic Drug Uptake (2011, background): “…octapeptide, dehydroepiandrosterone sulfate, es- tradiol-17␤-D-glucuronide, and estrone-3-sulfate are substrates of OATP1B1 (Abe et al., 1999; König et al., 2000b; Tamai et al., 2000; Cui et al., 2001; Nakai et al., 2001; Tamai et al., 2001; Sasaki et al., 2002; Hirano et al., 2004; Kopplow…”
• OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies (2012, background): “OATP1B1 and OATP1B3 are both selectively expressed in the liver (Abe et al., 1999; 2001; Hsiang et al., 1999; Konig et al., 2000a,b), where they are localized to the basolateral membrane of hepatocytes (Konig et al., 2000b; Abe et al., 2001; Kullak-Ublick et al., 2001; Cui et al., 2003).”
• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, positive): “Like OATP1B1, OATP1B3 is also polymorphically expressed.”
• Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties (2004, background): “Expression of OATP1B1 appears to be restricted to the basolateral (sinusoidal) plasma membrane of hepatocytes [3, 29, 30, 31] (Fig.”