The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling

By M. Karin, M. Delhase. 2000

923 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/59a71d786b81b1d96af2aff52a70b788a94d0d52

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. J. Hong
2. M. Park
3. R. Medzhitov
4. D. Krappmann
5. C. Scheidereit
6. Shizuo Akira

In Immunology

1. J. Hong
2. M. Park
3. R. Medzhitov
4. Shizuo Akira
5. Taro Kawai
6. Jonathan C. Kagan
7. Daniel B. Stetson
8. T. Mogensen

In Molecular Biology

1. J. Hong
2. M. Park
3. R. Medzhitov
4. D. Krappmann
5. C. Scheidereit
6. Kevin J. Tracey

Citations in the corpus

• Shared Pathways of IκB Kinase-Induced SCFβTrCP-Mediated Ubiquitination and Degradation for the NF-κB Precursor p105 and IκBα (2001, background): “The NF-kB transcription factor family plays an evolutionarily conserved role in innate and adaptive immune responses, and its members are essential regulators of proinflammatory processes (12, 18, 33).”
• Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches (2016, background): “Wi h the degradation of IκB, the NF-κB complex then enters into the nucleus where it ca 'turn on' the expression of s veral genes that have DNA-binding sites f r NF-κB [22,23].”