Oscillatory Expression of the bHLH Factor Hes1 Regulated by a Negative Feedback Loop
By Hiromi Hirata, S. Yoshiura, T. Ohtsuka, Yasumasa Bessho, T. Harada, K. Yoshikawa, Ryoichiro Kageyama. Science, 2002
785 citations recorded by the source corpus.
Subfields: Endocrine and Autonomic Systems, Molecular Biology, Plant Science
View Paper: https://www.semanticscholar.org/paper/59546fffc714642b59ac72716837d859d0e570a6
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Endocrine and Autonomic Systems
In Molecular Biology
- Paolo Sassone-Corsi
- T. Ohtsuka
- A. Kriegstein
- Ryoichiro Kageyama
- Jan H. Lui
- David V. Hansen
- Hiromi Shimojo
- U. Schibler
In Plant Science
Citations in the corpus
- A web of circadian pacemakers. (2002, background): “Mice deficient in the essential clock gene mPer2 are cancer prone and display a dereg- pressing the transcription of its own gene (Hirata et al., 2002), similar to the mechanism observed for someulated temporal expression of genes involved in cell cycle regulation, such as c-Myc, Cyclin D1, Cyclin…”
- Autoinhibition with transcriptional delay: a simple mechanism for the zebrafish somitogenesis oscillator. (2003, neutral): “seen by Hirata et al. in cultured mammalian cells [ 18 ] search UK. are a possible example.”
- A clockwork web: circadian timing in brain and periphery, in health and disease (2003, background): “Although other oscillatory systems, such as somite developmen”
- Development and Evolution of the Human Neocortex (2011, positive): “An important insight came when HES1 expression was found to oscillate at 2–3 hr intervals in cultured cells due to negative autoregulation of Hes1 transcription (Hirata et al., 2002).”
- The Hes gene family: repressors and oscillators that orchestrate embryogenesis (2007, background): “Hes1 is a cellular oscillator Expression of Hes1 can be induced following serum stimulation or Notch activation in many cell types, such as fibroblasts, myoblasts and neuroblasts; however, strikingly, the induced expression is oscillatory (Hirata et al., 2002).”
- [P2.15]: Oscillations in notch signaling regulate maintenance of neural progenitors (2008, positive): “Persistent expression of Dll1 protein would also induce Hes1 oscillation, because the addition of cells that persistently express Dll1 can induce Hes1 oscillation (Hirata et al., 2002).”