PKA dynamics in a Drosophila learning center: coincidence detection by rutabaga adenylyl cyclase and spatial regulation by dunce phosphodiesterase.

By N. Gervasi, P. Tchénio, T. Préat. 2010

220 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Organic Chemistry, Pharmacology

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In Cellular and Molecular Neuroscience

In Organic Chemistry

Seth M. Tomchik

In Pharmacology

Citations in the corpus

Dopaminergic neurons write and update memories with cell-type-specific rules (2016, background): “…Dopamine signaling to KCs has been implicated in both learning and forgetting (Schwaerzel et al., 2003; Schroll et al., 2006, Kim et al., 2007; Tomchik and Davis, 2009; Gervasi et al., 2010; Qin et al., 2012; Placais et al., 2012; Berry et al., 2012; Boto et al., 2014; Shuai et al., 2015).”
Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “cyclase encoded by the rutabaga gene, are required specifically in the KCs for memory formation (Livingstone et al., 1984; Zars et al., 2000; Schwaerzel et al., 2003; Kim et al., 2007; McGuire et al., 2003; Gervasi et al., 2010; Qin et al., 2012) and rutabaga was shown to be required for the establi”
A connectome of a learning and memory center in the adult Drosophila brain (2017, background): “…1 p e d c > α /β (2 ) α lobe DPM APL dependent adenylate cyclase rutabaga, which initiates a cAMP signaling cascade that leads to the biochemical changes underlying synaptic plasticity (Livingstone et al., 1984; Levin et al., 1992; Boto et al., 2014; Gervasi et al., 2010; Tomchik and Davis, 2009).”
Reward signal in a recurrent circuit drives appetitive long-term memory formation (2015, unknown): “These results are consistent with the observation that the coincidence detector adenylate cyclase encoded by rutabaga, thought to act downstream of the dopamine receptor (Tomchik and Davis, 2009; Gervasi et al., 2010; Boto et al., 2014), functions for LTM in the α/β KCs (Trannoy et al., 2011).”
Bruchpilot, A Synaptic Active Zone Protein for Anesthesia-Resistant Memory (2011, background): “This hypothesis may be tested in future by the identification of extrinsic neurons that are specifically required for ARM and corresponding functional imaging of memory traces (Yu et al., 2005; Mao and Davis, 2009; Tomchik and Davis, 2009; Gervasi et al., 2010).”
Pain-relief learning in flies, rats, and man: basic research and applied perspectives (2014, background): “It is likely that during punishment-training the type I adenylate cyclase rutabaga (CG9533) acts as a molecular detector of the coincidence between a neuromodulatory reinforcement signal and the odor-evoked activity in the mushroom body Kenyon cells (Tomchik and Davis 2009; Gervasi et al. 2010).”
Distinct dopamine receptor pathways underlie the temporal sensitivity of associative learning (2019, background): “cAMP was maximally evoked when KC and DAN stimulation were synchronous, matching the timing that gave rise to the strongest depression of KC-MBON signaling (Figures 2E and 5E) and consistent with evidence that calcium-sensitive adenylate cyclases serve as molecular coincidence detectors to amplify c”
Specific dopaminergic neurons for the formation of labile aversive memory (2010, unknown): “Type I adenylyl cyclase, Rutabaga, is an underlying molecular coincidence detector that forms a memory trace [6, 26, 43, 44].”
Dopamine Signalling in Mushroom Bodies Regulates Temperature-Preference Behaviour in Drosophila (2011, background): “cAMP [39,40] and dopaminergic neurons have a strong”
Event Timing in Associative Learning: From Biochemical Reaction Dynamics to Behavioural Observations (2012, background): “Also, degradation of cAMP [35] and de-phosphorylation of key downstream proteins [61] is likely critical for restricting the effects of learning both during training and thereafter.”
Dopaminergic neurons encode a distributed, asymmetric representation of temperature in Drosophila (2013, background): “2009) and protein kinase A (Gervasi et al., 2010), providing a mechanism through which mushroom bodies integrate information about sensory stimuli and dopaminergic circuit activity.”
Conditional modulation of spike-timing-dependent plasticity for olfactory learning (2012, background): “, and second-messenger pathways involved in memorization and retrieval have been described in Drosophila”
Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability (2012, background): “Considering the importance of the vertical lobes in olfactory learning [8,9,39,40,41,42], MB-MV1 neuron might act together with MB-V1 neuron during memory acquisition.”