Silver Nanoparticles: Synthesis and Application for Nanomedicine

By Sang Hun Lee, Bong-Hyun Jun. International Journal of Molecular Sciences, 2019

1,192 citations recorded by the source corpus.

Over the past few decades, metal nanoparticles less than 100 nm in diameter have made a substantial impact across diverse biomedical applications, such as diagnostic and medical devices, for personalized healthcare practice. In particular, silver nanoparticles (AgNPs) have great potential in a broad range of applications as antimicrobial agents, biomedical device coatings, drug-delivery carriers, imaging probes, and diagnostic and optoelectronic platforms, since they have discrete physical and optical properties and biochemical functionality tailored by diverse size- and shape-controlled AgNPs. In this review, we aimed to present major routes of synthesis of AgNPs, including physical, chemical, and biological synthesis processes, along with discrete physiochemical characteristics of AgNPs. We also discuss the underlying intricate molecular mechanisms behind their plasmonic properties on mono/bimetallic structures, potential cellular/microbial cytotoxicity, and optoelectronic property. Lastly, we conclude this review with a summary of current applications of AgNPs in nanoscience and nanomedicine and discuss their future perspectives in these areas.

Subfields: Electronic, Optical and Magnetic Materials, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/4214df28986cca889ea40669dafcffeeb435887d

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Citations in the corpus

• Antibacterial approaches in tissue engineering using metal ions and nanoparticles: From mechanisms to applications (2021, background): “For example, their size-, shape, and surface can be controlled during synthesis, and their biochemical functionality tailored to the respective application [66].”
• Metal-Based Nanoparticles as Antimicrobial Agents: An Overview (2020, background): “On the other hand, AgNPs are able to stimulate DNA damage, due to their genotoxic potential, breaking DNA chains and causing chromosomal aberrations [123].”
• Nanoparticles as Novel Elicitors to Improve Bioactive Compounds in Plants (2021, background): “These characteristics affect the cellular internalization, circulation time, biodistribution and residency time through the cells [35,44].”