Extended interneuronal network of the dentate gyrus

By Gergely G. Szabo, Xixi Du, M. Oijala, Csaba Varga, J. Parent, Ivan Soltesz. 2017

50 citations recorded by the source corpus.

SUMMARY Local interneurons control principal cells within individual brain areas, but anecdotal observations indicate that interneuronal axons sometimes extend beyond strict anatomical boundaries. Here we use the case of the dentate gyrus (DG) to show that boundary-crossing interneurons with cell bodies in the CA3 and CA1 constitute a numerically significant and diverse population that relays patterns of activity generated within the CA regions back to granule cells. These results reveal the existence of a sophisticated retrograde GABAergic circuit that fundamentally extends the canonical interneuronal network.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Re-evaluating circuit mechanisms underlying pattern separation (2019, positive): “, 2018) in specific regions - dentate granule cells are interconnected with multiple inhibitory interneuron subtypes, which are likely to be specialized for distinct functions (Halasy and Somogyi, 1993; Sik et al., 2006; Hosp et al., 2014; Savanthrapadian et al., 2014; Szabo et al., 2017).”