Mitochondria as all‐round players of the calcium game

By R. Rizzuto, P. Bernardi, T. Pozzan. Journal of Physiology, 2000

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Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology. (2010, background): “Mitochondria also serve as high-capacity Ca sinks, which allows them to stay in tune with changes in cytosolic Ca loads and aid in maintaining cellular Ca homeostasis that is required for normal neuronal function [14].”
Mitochondria and calcium: from cell signalling to cell death (2000, methodology): “In addition to the use of mitochondrially targeted aequorin (described by Rizzuto et al. 2000, this issue, and see Brini et al. 1995), it has recently become possible to measure Ca¥ uptake into mitochondria directly using the fluorescent [Ca¥] indicator rhod-2.”
The mitochondrial calcium uniporter is a highly selective ion channel (2004, background): “jpg" NDATA ITEM> ]> During intracellular Ca 2p signalling mitochondria accumulate significant amounts of Ca 2p from the cytoso”
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. (2006, background): “, 2003), Ca signaling (Rizzuto et al., 2000), and integration and amplification of apoptotic signals (Green and Kroemer, 2004).”