The diverse functions of GAPDH: views from different subcellular compartments

By Carlos A. Tristan, Neelam Shahani, T. Sedlak, A. Sawa. Cellular Signalling, 2010

634 citations recorded by the source corpus.

Multiple roles for glyceraldehyde-3-phosphate dehydrogenase (GAPDH) have been recently appreciated. In addition to the cytoplasm where majority of GAPDH is located under the basal condition, GAPDH is also found in the particulate fractions, such as the nucleus, the mitochondria, and the small vesicular fractions. When cells are exposed to various stressors, dynamic subcellular re-distribution of GAPDH occurs. Here we review these multifunctional properties of GAPDH, especially linking them to its oligomerization, posttranslational modification, and subcellular localization. This includes mechanistic descriptions of how S-nitrosylation of GAPDH under oxidative stress may lead to cell death/dysfunction via nuclear translocation of GAPDH, which is counteracted by a cytosolic GOSPEL. GAPDH is also involved in various diseases, especially neurodegenerative disorders and cancers. Therapeutic strategies to these conditions based on molecular understanding of GAPDH are discussed.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5867df85ad371c73896e907042ae77e05740d4de

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In Epidemiology

1. Edward J. Pearce
2. Craig B. Thompson
3. Erika L. Pearce
4. Beth Levine
5. Guido Kroemer

In Molecular Biology

1. Erika L. Pearce
2. Russell G. Jones
3. David O’Sullivan
4. Chih-Hao Chang
5. B. Faubert
6. Edward J. Pearce
7. Craig B. Thompson
8. Chao Lu

Citations in the corpus

• Metabolic regulation of epigenetics (2012, background): “Alternatively metabolic enzymes may function in these complexes independently of their metabolic activity (Tristan et al., 2011; Yang et al., 2011).”
• Posttranscriptional control of T cell effector function by aerobic glycolysis. (2013, positive): “It is also known that the activity of GAPDH is heavily influenced by the redox state of a cell and that redox-mediated changes can alter its function and even location within different cellular compartments (Colell et al., 2007; Tristan et al., 2011).”
• Genes and growth performance in crustacean species : a review of relevant genomic studies in crustaceans and other taxa (2013, background): “GAPDH was once considered to be a simple housekeeping protein but has recently been shown to be involved in many cellular processes in addition to glycolysis (Sirover 2011; Tristan et al. 2011).”