Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains.

By J. Rice, S. Briggs, B. Ueberheide, C. Barber, J. Shabanowitz, D. Hunt, Y. Shinkai, C. D. Allis. Molecules and Cells, 2003

823 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/581028f9645923e0786afede60aceb59564963ed

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Citations in the corpus

• Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. (2005, background): “As reported previously (Peters et al. 2003; Rice et al. 2003), Western blot analysis clearly showed that H3-K9 mono- and dimethylation was severely diminished in the G9a ES cells (Fig.”
• The diverse functions of histone lysine methylation (2005, background): “In mice, two Clr4 homologues, SUV39h1 and SUV39h2, are responsible for H3-K9 methylation at heterochromatic regions such as pericentric heterochromatin 18,48,49 .”
• From silencing to gene expression: real-time analysis in single cells. (2004, methodology): “As G9a has been reported to be a H3 K9 di-HMTase (Rice et al., 2003; Peters et al., 2003)lac repressor (Figures 4P–4R; Supplemental Data, Sup- plemental Figure S4 available on Cell website, Western and Eu-HMTase1 is 63% homologous to G9a and possesses the same basic structure (Ogawa et al.,…”
• Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. (2006, background): “In addition to a role in embryonic development, methylation is also intricately associated with the silencing of the X chromosome and euchromatic regions in a number of organisms (Cowell et al., 2002; Lucchesi et al., 2005; Rice et al., 2003; Peters et al., 2003).”
• The X and Y Chromosomes Assemble into H2A.Z, Containing Facultative Heterochromatin, following Meiosis (2006, background): “Mouse facultative heterochromatin is defined by a different set of histone posttranslational modifications, H3-K9 dimethylation and H3-K27 trimethylation (46, 53).”