A newly discovered human pneumovirus isolated from young children with respiratory tract disease

By B. G. van den Hoogen, J. D. de Jong, J. Groen, T. Kuiken, R. de Groot, R. Fouchier, A. Osterhaus. Nature Medicine, 2001

2,178 citations recorded by the source corpus.

From 28 young children in the Netherlands, we isolated a paramyxovirus that was identified as a tentative new member of the Metapneumovirus genus based on virological data, sequence homology and gene constellation. Previously, avian pneumovirus was the sole member of this recently assigned genus, hence the provisional name for the newly discovered virus: human metapneumovirus. The clinical symptoms of the children from whom the virus was isolated were similar to those caused by human respiratory syncytial virus infection, ranging from upper respiratory tract disease to severe bronchiolitis and pneumonia. Serological studies showed that by the age of five years, virtually all children in the Netherlands have been exposed to human metapneumovirus and that the virus has been circulating in humans for at least 50 years.

Subfields: Epidemiology, Infectious Diseases, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/57d3b37d7a02dd257ac618b4f9b1c950b77c6027

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Yi Guan
2. H. Talbot
3. Marie R. Griffin
4. Kathryn M. Edwards
5. John V. Williams
6. Kyle Widmer
7. I. Mackay
8. Yuwei Zhu

In Infectious Diseases

1. Kwok-Yung Yuen
2. Patrick C. Y. Woo
3. Kwok-Hung Chan
4. Yi Huang
5. H. Tsoi
6. Susanna K. P. Lau

In Pulmonary and Respiratory Medicine

1. H. Talbot
2. Marie R. Griffin
3. Kathryn M. Edwards
4. John V. Williams
5. Kyle Widmer
6. Yuwei Zhu

Citations in the corpus

• Parainfluenza Viruses (2003, background): “Recently discovered members of the Paramyxoviridae (megamyxoviruses [Hendra and Nipah viruses] and metapneumovirus) emphasize this point (53, 254, 265, 360).”
• Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults. (2012, background): “In addition, RSV and HMPV are difficult to culture [19–21].”
• Characterization and Complete Genome Sequence of a Novel Coronavirus, Coronavirus HKU1, from Patients with Pneumonia (2005, background): “Of the three novel agents identified in recent 3 years, including human metapneumovirus (36), severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) (25), and human coronavirus NL63 (HCoV-NL63) (6, 37), two were coronaviruses.”
• Identification of a Novel Polyomavirus from Patients with Acute Respiratory Tract Infections (2007, background): “In fact, since 2001, six previously undescribed viruses have been identified by analysis of clinical specimens from the human respiratory tract: human metapneumovirus [3], SARS coronavirus [4], coronavirus NL63 [5], coronavirus HKU1 [6], human bocavirus [7], and the recently described KI virus [8].”
• Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups. (2002, background): “We were able to report the growth of HMPV in LLC-MK2 cells, an established cell line used to identify parainfluenzaviruses, but not in other cell lines (MDCK and Hep-2) that are often used to isolate respiratory viral pathogens [1].”
• Real-Time PCR in Clinical Microbiology: Applications for Routine Laboratory Testing (2006, background): “In 2001, a new virus from children and adults with acute respiratory tract infections was identified (503, 545).”