Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion.
By C. Enroth, B. Eger, K. Okamoto, T. Nishino, E. Pai. Proceedings of the National Academy of Sciences of the United States of America, 2000
649 citations recorded by the source corpus.
Subfields: Molecular Biology, Nephrology
View Paper: https://www.semanticscholar.org/paper/57af3c43373df3410e35441ee179d9c2a4866484
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In Molecular Biology
- J. Hare
- C. Berry
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- Rob Knight
- Curtis Huttenhower
- Micah Hamady
- Patrick D. Schloss
- Catherine A. Lozupone
In Nephrology
Citations in the corpus
- Aldehyde Sources, Metabolism, Molecular Toxicity Mechanisms, and Possible Effects on Human Health (2005, background): “X-ray crystallography showed that XO was formed from XDH by a reversible oxidation of Cys535 and Cys992 or if the peptide chain was knicked by a Ca2+-activated irreversible proteolysis, which caused a peptide chain rearrangement that partially blocked NAD+ access to the FAD site (Enroth et al., 2000”
- Structure and function of xanthine oxidoreductase: where are we now? (2002, background): “The side chain of Asp 429 is removed from its close contact with the flavin ring and replaced by Arg 426 [100].”
- The DMSO Reductase Family of Microbial Molybdenum Enzymes; Molecular Properties and Role in the Dissimilatory Reduction of Toxic Elements (2002, background): “…(Chan et al. 1995), and the dimethylsulfoxide (DMSO) reductase family (Chan et al. 1995; Romao et al. 1995; Schindelin et al. 1996; Schneider et al. 1996; Boyington et al. 1997; McAlpine et al. 1997; Czjzek et al. 1998; Dias et al. 1999; Dobbek et al. 1999; Enroth et al. 2000; Ellis et al. 2001).”
- Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications (2004, background): “Similarities between the crystal structures of aldehyde oxidoreductase and bovine XOR suggest the coordination of the molybdenum ion in aldehyde oxidoreductase may apply to XOR as well (Romão et al. 1995; Huber et al. 1996; Enroth et al. 2000).”
- Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol (2006, background): “The FAD cofactor, the two iron/sulfur centers, the molybdopterin cofactor, and the salicylate also are included (Enroth et al., 2000) ).”
- Molybdenum cofactors, enzymes and pathways (2009, background): “In bacteria, such as Rhodobacter capsulatus , xanthine dehydrogenase assembles from two different subunits, harbouring the Moco on one subunit and the iron-containing and FAD-containing domains on the other subunit and showing a remarkable structural and functional similarity to the bovine enzym”