Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria

By T. Ayabe, D. Satchell, Carole L Wilson, W. Parks, M. Selsted, A. Ouellette. Nature Immunology, 2000

924 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Food Science, Microbiology

View Paper: https://www.semanticscholar.org/paper/57912a0d31931e1f6d6f2153a525035a085ac9d5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Emergency Medical Services

1. Shizuo Akira
2. K. Takeda
3. M. Abreu
4. Taro Kawai

In Food Science

1. L. Hooper
2. Herbert Tilg

In Microbiology

1. Shizuo Akira
2. K. Takeda
3. S. Ghosh
4. M. Malmsten
5. Mukesh Pasupuleti
6. M. Abreu
7. T. Kaisho
8. A. Schmidtchen

Citations in the corpus

• NF-κB and the immune response (2006, background): “Small intestinal Paneth cells, for example, release large amounts of a-defensins into the intestinal lumen following exposure to a variety of bacteria/bacterial products (Ayabe et al., 2000).”
• XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease (2008, positive): “Cell 134, 743–756, September 5, 2008 ª2008 Elsevier Inc. 751”
• TLR Signaling in the Gut in Health and Disease1 (2005, background): “The -defensins, HD5 and HD6, are expressed by Paneth cells (29), and either whole bacteria or PAMPs such as LPS, LTA, and muramyl dipeptide stimulate release of defensins (30) suggesting that Paneth cells express a wide range of TLRs.”