The genetic design of signaling cascades to record receptor activation
By G. Barnea, W. Strapps, G. Herrada, Y. Berman, Jane Ong, B. Kloss, R. Axel, Kevin J. Lee. Proceedings of the National Academy of Sciences of the United States of America, 2008
651 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/5768e9bed22398a16a223d204bba2d7287aac2e5
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cellular and Molecular Neuroscience
- David E. Gloriam
- Raymond C. Stevens
- Vsevolod Katritch
- Bryan L. Roth
- Jianzhi Zeng
- Wendell A. Lim
- A. Kreitzer
- Vadim Cherezov
In Molecular Biology
- Wendell A. Lim
- David E. Gloriam
- Vsevolod Katritch
- Raymond C. Stevens
- Bryan L. Roth
- Kasper Harpsøe
- Shuguang Yuan
- A. Kreitzer
In Radiology, Nuclear Medicine and Imaging
Citations in the corpus
- Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors (2016, background): “The very direct mechanism of Notch signaling has also inspired the engineering of novel proteolytically induced receptors and reporter systems (Barnea et al., 2008; Daringer et al., 2014).”
- PRESTO-TANGO: an open-source resource for interrogation of the druggable human GPCR-ome (2015, positive): “At the 3 ′ end, we included the sequences for the tobacco etch virus nuclear inclusion a endopeptidase (TEV)- cleavage site and the tetracycline transactivator (tTA) protein, exactly as previously published 20 .”
- 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology (2018, positive): “…et al., 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology, Cell (2018), https://doi.org/10.1016/j.cell.2018.01.001 cells (HEK293-derived, female, gift from Dr. Richard Axel) that express TEV fused-b-arrestin2 and tTA-driven luciferase reporter (Barnea et al., 2008).”
- A genetically-encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice (2018, methodology): “The TANGO assay, as well as next-generation versions (Barnea et al., 2008; Inagaki et al., 2012; Kim et al., 2017; Lee et al., 2017), have been used to measure endogenous DA release by coupling the b-arrestin signaling pathway to the expression of reporter genes.”