SOCS Proteins: Negative Regulators of Cytokine Signaling

By D. Krebs, D. Hilton. Stem Cells, 2001

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STAT proteins: From normal control of cellular events to tumorigenesis (2003, background): “The SOCS proteins are recruited to active receptor complexes to cause inhibition, and can also cause protein turnover of the receptor through a process of proteolytic degradation ubiquitine-proteasome mediated (Krebs and Hilton, 2001).”
Interferon signaling and treatment outcome in chronic hepatitis C (2008, background): “Prominent candidates among the negative regulators are suppressors of cytokine signaling 1 (SOCS1) and SOCS3 (29), two IFN-induced proteins that bind to the IFN receptor and inhibit the activity of Jak1 and Tyk2, and the more recently described regulator Ubp43 (protein of the USP18 gene), an IFN-sti”
Signalling: STATs: transcriptional control and biological impact (2002, neutral): “These cytokine-inducible kinase inhibitors are fairly promiscuous, both in their effect on the induction of different cytokines and in their ability to inhibit distinct receptor–kinase complexe”
Viruses and interferon: a fight for supremacy (2002, methodology): “Specifically, viruses that were deleted of the NS1 gene induced a general increase in the transcription of ISGs and NF-κB-mediated gene expression compared with wild-type virus, and were observed to differentially regulate genes of the suppressor of cytokine signalling (SOCS) family, which modulat”