Bioglass ®45S5 Stimulates Osteoblast Turnover and Enhances Bone Formation In Vitro: Implications and Applications for Bone Tissue Engineering

By I. Xynos, M. Hukkanen, J. Batten, L. Buttery, L. Hench, Julia M. Polak. Calcified Tissue International, 2000

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Structural models of bioactive glasses from molecular dynamics simulations (2009, background): “This could be related to the release of specific amounts of Si, P, Na and Ca ions, whose local concentration in the physiological environment can approach critical values needed to stimulate the cellular activity (Xynos et al. 2000, 2001; Hench & Polak 2002; Day 2005; Boccaccini et al. 2007).”
Review of bioactive glass: from Hench to hybrids. (2013, background): “Extracellular matrix secretion was also increased, which mineralized without addition of supplements [118,119].”
Porosity of 3D biomaterial scaffolds and osteogenesis. (2005, background): “Glasses Sintering 100–200 5 [63] 40 Tibia defects in rabbits [73] Bioglass Foaming 10–500 Primary human osteoblasts in vitro [74,75] Sintering 100–600 Ectopic bone formation in dogs [65] Glass-ceramics Sintering 100–200 [63] Phase transformation 10–300 51, 47 and 43 Femoral defects in rabbits [53] T”
Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. (2006, background): “Investigations in vivo have shown that bone ingrowth into silicon-substituted HA granules was remarkably greater than that into pure HA [92].”