Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

By D. Lando, D. Peet, Dean A Whelan, J. Gorman, M. Whitelaw. Science, 2002

1,610 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/56986a3761858ed94221534104f97dacadfc3a98

How researchers see this paper

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In Cancer Research

1. G. Semenza
2. M. C. Simon
3. Amato J. Giaccia
4. Craig B. Thompson
5. Richard J. Johnson
6. Erinn B. Rankin
7. Eyal Gottlieb
8. Max Costa

In Molecular Biology

1. G. Semenza
2. M. C. Simon
3. Amato J. Giaccia
4. Craig B. Thompson
5. Richard J. Johnson
6. Eyal Gottlieb
7. N. Prabhakar
8. J. Espinosa

In Physiology

1. G. Semenza
2. Amato J. Giaccia
3. M. C. Simon
4. Richard J. Johnson
5. V. Haase
6. Erinn B. Rankin
7. Robert P. Hausinger
8. Eyal Gottlieb

Citations in the corpus

• Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. (2005, background): “The transcriptional activity of HIF-(cid:1) is also regulated by hydroxylation of an asparaginyl residue in its C-terminal transactivation domain in a reaction catalyzed by factor inhibiting HIF (FIH) (Hewitson et al., 2002; Lando et al., 2002a,2002b).”
• Transcriptional Regulation by Hypoxia Inducible Factors (2013, background): “…confirmed the interaction between HIF1A/2A and CBP/p300, and established that the interaction occurs through the HIF C-TADs and is regulated by hydroxylation (Carrero et al., 2000; Ebert & Bunn, 1998; Ema et al., 1997; Huang et al., 1996; Lando et al., 2002b; Ruas et al., 2002; Ziel et al., 2004).”
• Hypoxia-Inducible Factor-1 (HIF-1) (2006, background): “Under normal oxygen tension, hydroxylation of the asparagines residue 803 (Asn803) in the C-TAD of HIF-1 (Asn851 in HIF-2 ) by factor inhibiting HIF-1 (FIH-1) prevented the interaction of HIF-1 with CBP/p300 (Hewitson et al., 2002; Lando et al., 2002b; Sang et al., 2002).”
• Pyruvate Kinase M2 is a PHD3-stimulated Coactivator for Hypoxia-Inducible Factor 1 (2011, positive): “Hydroxylation of HIF-1a at asparagine-803, which is catalyzed by the asparaginyl hydroxylase FIH-1 in normoxic cells, blocks the binding of the transcriptional coactivator p300 to HIF-1a (Lando et al., 2002).”
• ADAPTIVE AND MALADAPTIVE CARDIORESPIRATORY RESPONSES TO CONTINUOUS AND INTERMITTENT HYPOXIA MEDIATED BY HYPOXIA-INDUCIBLE FACTORS 1 AND 2 (2012, background): “973Physiol Rev • VOL 92 • JULY 2012 • www.prv.org by 10.220.32.246 on A ugust 27, 2017 http://physrev.physiology.org/ D ow nloaded from 803 located in the TAD-C (FIGURE 3) blocks the binding of the coactivators p300 and CBP (181).”