STING: infection, inflammation and cancer
By G. Barber. Nature reviews. Immunology, 2015
1,177 citations recorded by the source corpus.
The rapid detection of microbial agents is essential for the effective initiation of host defence mechanisms against infection. Understanding how cells detect cytosolic DNA to trigger innate immune gene transcription has important implications — not only for comprehending the immune response to pathogens but also for elucidating the causes of autoinflammatory disease involving the sensing of self-DNA and the generation of effective antitumour adaptive immunity. The discovery of the STING (stimulator of interferon genes)-controlled innate immune pathway, which mediates cytosolic DNA-induced signalling events, has recently provided important insights into these processes, opening the way for the development of novel immunization regimes, as well as therapies to treat autoinflammatory disease and cancer.
Subfields: Immunology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/1ed655394c2871f40550f0a374c28ed74a52a03b
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Citations in the corpus
- cGAS surveillance of micronuclei links genome instability to innate immunity (2017, positive): “Aberrant recognition of immunostimulatory cytosolic DNA has been implicated in neoplasia and systemic autoinflammatory disease12–14, with cGAS/ STING-dependent inflammation associated with mutations in multiple nucleases15.”
- Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence (2017, positive): “Upon activation, cGAS synthesizes the second messenger molecule 2`3`cyclic GMP-AMP (cGAMP), which engages STING, thereby leading to the production of inflammatory cytokines, chemokines and type I interferons (IFNs) 19 20 21 22, 23 24 25.”
- Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021, background): “It also differentially regulates translation of IL-1A, the master regulator of SASP that subsequently engages IL-6/IL-8 (Orjalo et al., 2009; Laberge et al., 2015) and MAP kinase-activated protein kinase 2 (MAPKAP2) through 4EBP1, a translation repressor protein (Herranz et al., 2015).”
- Targeting DNA damage response promotes anti-tumor immunity through STING-mediated T-cell activation in small cell lung cancer (2019, background): “In contrast, treatment with PTX (10 and 20 μmol/L for 48 hours) did not cause any appreciable change in the mRNA expression of IFNβ (Supplementary Fig.”