CpG methylation of half-CRE sequences creates C/EBPα binding sites that activate some tissue-specific genes

By V. Rishi, P. Bhattacharya, R. Chatterjee, J. Rozenberg, Jianfei Zhao, Kimberly Glass, P. FitzGerald, C. Vinson. 2010

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Impact of cytosine methylation on DNA binding specificities of human transcription factors (2017, background): “In contrast to most previously reported cases [for example, (9, 10, 12, 17, 18)], we found that methylation can affect TF binding positively in many cases [see also (16, 62)].”
CG methylated microarrays identify a novel methylated sequence bound by the CEBPB|ATF4 heterodimer that is active in vivo (2013, methodology): “Both the CEBP and CRE motifs have a CG dinucleotide at the center of the transcription factor binding site (TFBS) and methylation has opposite effects on the DNA binding: it enhances CEBPA binding and inhibits CREB binding (Iguchi-Ariga and Schaffner 1989; Rishi et al. 2010).”
DNA methylation presents distinct binding sites for human transcription factors (2013, background): “In this study we have identified numerous human TFs across various subfamilies that showed mCpG- and sequence-dependent binding activity, a much more prevalent phenomenon than previously appreciated (Karlsson et al., 2008; Rishi et al., 2010; Quenneville et al., 2011; Liu et al., 2012).”
High-resolution genome-wide DNA methylation maps of mouse primary female dermal fibroblasts and keratinocytes (2014, unknown): “[8]).”