Skin photoprotection by natural polyphenols: Anti-inflammatory, anti-oxidant and DNA repair mechanisms

By J. A. Nichols, S. Katiyar. Archives of Dermatological Research, 2009

1,011 citations recorded by the source corpus.

Epidemiological, clinical and laboratory studies have implicated solar ultraviolet (UV) radiation in various skin diseases including, premature aging of the skin and melanoma and non-melanoma skin cancers. Chronic UV radiation exposure-induced skin diseases or skin disorders are caused by the excessive induction of inflammation, oxidative stress and DNA damage, etc. The use of chemopreventive agents, such as plant polyphenols, to inhibit these events in UV-exposed skin is gaining attention. Chemoprevention refers to the use of agents that can inhibit, reverse or retard the process of these harmful events in the UV-exposed skin. A wide variety of polyphenols or phytochemicals, most of which are dietary supplements, have been reported to possess substantial skin photoprotective effects. This review article summarizes the photoprotective effects of some selected polyphenols, such as green tea polyphenols, grape seed proanthocyanidins, resveratrol, silymarin and genistein, on UV-induced skin inflammation, oxidative stress and DNA damage, etc., with a focus on mechanisms underlying the photoprotective effects of these polyphenols. The laboratory studies conducted in animal models suggest that these polyphenols have the ability to protect the skin from the adverse effects of UV radiation, including the risk of skin cancers. It is suggested that polyphenols may favorably supplement sunscreens protection, and may be useful for skin diseases associated with solar UV radiation-induced inflammation, oxidative stress and DNA damage.

Subfields: Cell Biology, Dermatology, Insect Science

View Paper: https://www.semanticscholar.org/paper/5662918fdfbd62059cbdd39c991ab3acb67a1f9a

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Citations in the corpus

• Fabrication of uniform lignin colloidal spheres for developing natural broad-spectrum sunscreens with high sun protection factor (2017, neutral): “DNA (Nichols and Katiyar, 2010).”
• Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases (2015, background): “Furthermore, green tea polyphenols, silymarin from milk thistle, and proanthocyanidins from grape seeds, had the ability to protect the skin from the adverse effects of UV radiation, such as the risk of skin cancers [90].”