Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution

By Yufeng Zhou, J. Morais-Cabral, A. Kaufman, R. MacKinnon. Nature, 2001

2,016 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/565d9a42c047480ab39c180ccd446a399d60f595

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Citations in the corpus

Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. (2002, background): “In K channels, the oxygens of the carbonyl groups of the polypeptide backbone at the selectivity filter act as surrogate water molecules for the dehydrated ion in the pore (64, 178, 273).”
Theoretical and computational models of biological ion channels (2004, background): “…wealth of information (Ketchem et al. 1997 ; Chang et al. 1998 ; Doyle et al. 1998 ; Schirmer, 1998 ; Morais-Cabral et al. 2001 ; Wang et al. 2001 ; Zhou et al. 2001a, b), theoretical considerations are necessary for elucidating the (hidden) microscopic factors governing ion conduction and…”
Biology, structure and mechanism of P-type ATPases (2004, background): “This specificity must reside in the precise geometry of the side chains in the ion-binding sites, as it does in ion channel”
A glimpse of structural biology through X-ray crystallography. (2014, background): “Tetrameric arrangement of the K selectivity filter and structural features of the pore provide explanations to ion selectivity and conduction (Doyle et al., 1998; Roux and MacKinnon, 1999; Zhou et al., 2001).”
Structure of a bacterial multidrug ABC transporter (2006, background): “Although obviously unique, CorA seems strangely reminiscent of the Kþ-type channels (Zhou et al, 2001; Zhou and MacKinnon, 2003; Shi et al, 2006); and we begin to draw A structural model of the CorA translocation cycle J Payandeh and EF Pai The EMBO Journal VOL 25 | NO 16 | 2006 &2006 European…”
Energetic optimization of ion conduction rate by the K+ selectivity filter (2001, neutral): “∆E (kT) Reaction coordinate (1,3) (2,4) ∆E”
Water in nonpolar confinement: from nanotubes to proteins and beyond. (2008, neutral): “For example, both glycerol (106) and potassium channels (121) have distinct binding sites that help partition their substrate as a prerequisite to transport.”