Structure of a bacterial multidrug ABC transporter

By R. Dawson, K. Locher. Nature, 2006

1,312 citations recorded by the source corpus.

Subfields: Molecular Medicine, Oncology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/55d03b961f582f327e24eb46454e8f1bced1a7ec

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Medicine

1. H. Nikaido
2. Xian-Zhi Li
3. E. Dassa
4. C. Orelle
5. K. Locher
6. A. Davidson
7. Jue Chen
8. Yigong Shi

In Oncology

1. S. Wilkens
2. Xian-Zhi Li
3. H. Nikaido
4. K. Locher
5. E. Dassa
6. C. Orelle
7. A. Davidson
8. Jue Chen

In Pharmacology

1. S. Wilkens
2. H. Nikaido
3. Xian-Zhi Li
4. Yigong Shi
5. F. Sharom
6. G. von Heijne
7. Mohamed A. Marahiel
8. K. Locher

Citations in the corpus

• Mechanistic diversity in ATP-binding cassette (ABC) transporters (2016, background): “However, several crystal structures are inconsistent with this simplified view 54-58 .”
• Membrane-protein topology (2006, background): “, giving rise to internally 2-fold symmetric 3D structure”
• Structure and mechanism of ABC transporters (2015, background): “A key structural element for coupling NBD to TMD events is the Q-loop (named so for a conserved glutamine residue) and the so-called “coupling helix” at the NBDTMD interface [36,38,48].”
• Siderophore-Based Iron Acquisition and Pathogen Control (2007, background): “aureus Sav1866 multidrug transporter (70).”
• A glimpse of structural biology through X-ray crystallography. (2014, background): “Crystal structures, including a bacterial multidrug transporter Sav1866 (Dawson and Locher, 2006), a putative metal-chelate-type transporter (Pinkett et al., 2007), a maltose transporter (Oldham et al., 2007), BtuCD bound to the periplasmic-binding protein BtuF (Hvorup et al., 2007), a bacterial lip”
• Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems (2008, background): “IM domains are typically comprised of six TM -helices, and several structures of intact transporters have been determined (102, 205, 285, 343, 366, 518).”
• ABC multidrug transporters: structure, function and role in chemoresistance. (2008, background): “Structure of ABC proteins There has been increasing success in crystallizing integral membrane proteins over the past few years, and the high resolution structures of several intact bacterial ABC proteins have been determined, including BtuCD [19], HI1470/1471 [20], ModB2C2 [21] and Sav1866 [22] (Fi”