Energetic optimization of ion conduction rate by the K+ selectivity filter

By J. Morais-Cabral, Yufeng Zhou, R. MacKinnon. Nature, 2001

802 citations recorded by the source corpus.

Subfields: Molecular Biology, Spectroscopy

View Paper: https://www.semanticscholar.org/paper/c6c55fa6e77df885cbc01e9bd606a89a796c96ef

How researchers see this paper

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In Molecular Biology

1. Wonpil Im
2. Benoît Roux
3. Yigong Shi
4. Menachem Elimelech
5. M. Jackson
6. V. Demidchik
7. Yifan Cheng
8. J. Massagué

In Spectroscopy

1. Benoît Roux
2. Wonpil Im
3. Yigong Shi

Citations in the corpus

• Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. (2002, background): “In K channels, the oxygens of the carbonyl groups of the polypeptide backbone at the selectivity filter act as surrogate water molecules for the dehydrated ion in the pore (64, 178, 273).”
• Molecular and Cellular Biophysics: Index (2006, background): “It contains four binding sites, which fill with two ions as the ion concentration is raised (Morais-Cabral et al., 2001).”
• Stress-induced electrolyte leakage: the role of K+-permeable channels and involvement in programmed cell death and metabolic adjustment. (2014, background): “As mentioned above, the idea of an ion channel mechanism of K efflux (passive permeability of the plasma membrane) was actually proposed by Palta et al. (1977), based on studies of freezing tolerance.”
• Maximizing the right stuff: The trade-off between membrane permeability and selectivity (2017, background): “channel (116), (F) aquaporin (93), and (G) the effect of hourglass pore design parameters (pore”
• Inwardly rectifying potassium channels: their structure, function, and physiological roles. (2010, background): “While the pore lining helices in the KcsA structure are arranged in a fourfold symmetry, those in KirBac1.”
• A glimpse of structural biology through X-ray crystallography. (2014, background): “Only two out of four potential K binding sites are occupied in the selectivity filter, allowing energy minimization and optimization of conduction rate (Morais-Cabral et al., 2001).”