Heart valve development: endothelial cell signaling and differentiation.

By Ehrin J. Armstrong, J. Bischoff. Circulation Research, 2004

693 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cardiology and Cardiovascular Medicine, Epidemiology

View Paper: https://www.semanticscholar.org/paper/5641cff4d72e96cc88fc68a252f4e0c0a8db0db9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. G. Vunjak‐Novakovic
2. A. Atala
3. A. Mikos
4. Deepak Srivastava

In Cardiology and Cardiovascular Medicine

1. Yibin Wang
2. Deepak Srivastava
3. T. Force

In Epidemiology

1. Yibin Wang
2. B. Rose
3. T. Force
4. Deepak Srivastava

Citations in the corpus

• Making or breaking the heart: from lineage determination to morphogenesis. (2006, background): “Reciprocal signaling, mediated in part by TGF-β family members, between the myocardium and endocardium in the cushion region induces a transformation of endocardial cells into mesenchymal cells that migrate into the extracellular matrix cushion (reviewed in Armstrong and Bischoff, 2004).”
• The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology. (2007, background): “Individual endothelial cells delaminate from the single layer of endothelium and invade into the cardiac jelly of the endocardial cushion.(6) This cellular migration and subsequent proliferation results in the transformation of the endothelial cells into VICs, and the cushion undergoes matrix remode”
• Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. (2010, background): “Camenisch et al. (60) have shown that in embryos deficient for Has2, an enzyme responsible for HA synthesis, endocardial cells overlaying the cardiac cushion forming area display reduced EMT and migration (60), a phenotype rescued by a constitutively active Ras.”
• Heart Valve Tissue Engineering: Concepts, Approaches, Progress, and Challenges (2006, background): “5 , 9 , 43 , 78 We studied the subsequent maturation and evolution of human semilunar valves in fetuses, neonates, children, and adults.”
• The Origin of Fibroblasts and Mechanism of Cardiac Fibrosis (2010, background): “Thereafter, transformed cells invade the cardiac jelly and mature into a fibroblastic phenotype (Armstrong and Bischoff, 2004; de Lange et al., 2004).”
• Engineering Complex Tissues (2006, positive): “It is well known that cellular recognition is facilitated by the binding of cell surface integrins to specific amino acid motifs of the ECM.”