A role for ghrelin in the central regulation of feeding
By M. Nakazato, N. Murakami, Y. Date, M. Kojima, H. Matsuo, K. Kangawa, S. Matsukura. Nature, 2001
3,531 citations recorded by the source corpus.
Subfields: Endocrine and Autonomic Systems, Nutrition and Dietetics, Physiology
View Paper: https://www.semanticscholar.org/paper/563f73950d2354cace2f835aee6258da51958f59
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Endocrine and Autonomic Systems
In Nutrition and Dietetics
In Physiology
Citations in the corpus
- Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. (2004, background): “As leptin and ghrelin exert antagonistic effects on food intake at the hypothalamic level (4, 6), we next sought to determine the mechanism by which these metabolic hormones regulate inflammatory cytokine production.”
- Expression of ghrelin receptor mRNA in the rat and the mouse brain (2006, background): “Interestingly, these dopaminergic VTA neurons have been highly studied due to their involvement in brain reward circuits, such as those associated with addictive substances (Nestler, 1996).”
- Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT (2002, background): “Ghrelin is a newly discovered hormone, which induces the release of growth hormone (GH)* and stimulates food intake and adiposity (Kojima et al., 1999; Tschop et al., 2000; Bowers, 2001; Inu, 2001; Nakazato et al., 2001).”
- Elevated plasma ghrelin levels in Prader–Willi syndrome (2002, background): “that increases food intake, body weight and growth-hormone (GH) secretion as potently as any known peptid”
- Reward Mechanisms in Obesity: New Insights and Future Directions (2011, background): “More recently, the hunger-related hormone ghrelin (Kojima et al., 1999; Nakazato et al., 2001) was shown to potentiate the activation of hedonic systems in the brain in response to food cues (Malik et al., 2008).”
- Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. (2001, background): “In addition, previous studies showed that GHS-R mRNA is expressed in a large population of arcuate neurons containing NPY (25).”