Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study.

By A. Anand, Y. Li, Yang Wang, Jingwei Wu, M. Lowe. Biological Psychiatry, 2005

828 citations recorded by the source corpus.

BACKGROUND Functional imaging studies indicate that imbalances in cortico-limbic activity and connectivity may underlie the pathophysiology of MDD. In this study, using functional Magnetic Resonance Imaging (fMRI), we investigated differences in cortico-limbic activity and connectivity between depressed patients and healthy controls. METHODS Fifteen unmedicated unipolar depressed patients and 15 matched healthy subjects underwent fMRI during which they first completed a conventional block-design activation experiment in which they were exposed to negative and neutral pictures. Next, low frequency blood oxygenation dependent (BOLD) related fluctuations (LFBF) data were acquired at rest and during steady-state exposure to neutral, positive and negative pictures. LFBF correlations were calculated between anterior cingulate cortex (ACC) and limbic regions--amygdala (AMYG), pallidostriatum (PST) and medial thalamus (MTHAL) and used as a measure of cortico-limbic connectivity. RESULTS Depressed patients had increased activation of cortical and limbic regions. At rest and during exposure to neutral, positive, and negative pictures cortico-limbic LFBF correlations were decreased in depressed patients compared to healthy subjects. CONCLUSIONS The finding of increased activation of limbic regions and decreased LFBF correlations between ACC and limbic regions is consistent with the hypothesis that decreased cortical regulation of limbic activation in response to negative stimuli may be present in depression.

Subfields: Cognitive Neuroscience, Experimental and Cognitive Psychology, Neurology

View Paper: https://www.semanticscholar.org/paper/5600c3ba93bb4ae7c411aa2e53fc94b935f5d07b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

In Experimental and Cognitive Psychology

In Neurology

Citations in the corpus

The proactive brain: memory for predictions (2009, background): “…the structure, function and connectivity of the same default / associative network are compromised in depression (Mayberg & Liotti 1999; Drevets 2000; Anand et al. 2005), and its integrity is improved with antidepressant-related clinical improvement (Mayberg & Liotti 1999; Anand et al. 2005).”
The experience of emotion. (2007, background): “…ventral system for core affect are implicated in a range of psychopathologies characterized by affective disturbances, including depression (e.g., Anand et al. 2005, Drevets 2000, Drevets et al. 1997, Hariri et al. 2005, Lacerda et al. 2004, Mayberg 1997, Pezawas et al. 2005), schizophrenia…”
Amplitude of low frequency fluctuation within visual areas revealed by resting-state functional MRI (2007, background): “, 2004), as well as within the cortico-limibic network in depression (Anand et al., 2005).”
Resting state functional connectivity in addiction: Lessons learned and a road ahead (2012, background): “…including: Alzheimer's disease (Greicius et al., 2004; Lustig et al., 2003; Rombouts et al., 2005; Wang et al., 2006), autism (Kennedy et al., 2006), depression (Anand et al., 2005), multiple sclerosis (Lowe et al., 2002), and attention deficit/hyperactive disorder (ADHD; Tian et al., 2006).”
An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI: fractional ALFF. (2008, neutral): “…in a wide range of brain disorders including Alzheimer's disease (Greicius et al., 2004; Wang et al., 2006), attention deficit hyperactivity disorder (Castellanos et al., 2008; Tian et al., 2006; Uddin et al., 2008), depression (Anand et al., 2005), schizophrenia (Jafri et al., 2008) and so on.”
Cognitive Deficits in Depression and Functional Specificity of Regional Brain Activity (2007, background): “In particular, it has been argued that decreased cortical activity is associated with increased activity in limbic regions (Anand et al., 2005; Mayberg & Fossati, in press).”
Correlations and anticorrelations in resting-state functional connectivity MRI: A quantitative comparison of preprocessing strategies (2009, neutral): “, 2004), and also within the cortico-limbic network in depression (Anand et al., 2005).”
The Development of Human Amygdala Functional Connectivity at Rest from 4 to 23 Years: a cross-sectional study (2014, neutral): “…in disrupted affective and cognitive processes in a range of clinical populations, including those with anxiety, depression, schizophrenia, and bipolar disorder (Anand et al., 2005; Berking and Wupperman, 2012; Cisler and Olatunji, 2012; Das et al., 2007; Henry et al., 2008; Wang et al., 2009).”
State-space model with deep learning for functional dynamics estimation in resting-state fMRI (2016, positive): “…Wang et al., 2007; Zhang et al., 2012; Chase, 2014), autism spectrum disorder (Monk et al., 2009; Khan et al., 2013), schizophrenia (Liang et al., 2006; Zhou et al., 2007; Garrity et al., 2007; Lynall et al., 2010), and depression (Anand et al., 2005; Greicius et al., 2007; Craddock et al., 2009).”
Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder (2011, background): “, 2009), depression (Anand et al., 2005), bipolar disorder (Wang et al.”
How Does Mindfulness Meditation Work? Proposing Mechanisms of Action From a Conceptual and Neural Perspective (2011, neutral): “…to a number of psychiatric disorders, and neuroimaging studies have shown that the aforementioned structures are dysfunctional in several psychiatric disorders, such as posttraumatic stress disorder (Milad et al., 2009), schizophrenia (Holt et al., 2009), and depression (Anand et al., 2005).”
Whole Brain Resting-State Analysis Reveals Decreased Functional Connectivity in Major Depression (2010, neutral): “In addition, support for reduced coupling between the dorsal ACC and seeds from the pallidostriatum and thalamus in MDD was not found, as has been described in previous studies (Anand et al., 2005a,b).”