The Development of Human Amygdala Functional Connectivity at Rest from 4 to 23 Years: a cross-sectional study
By Laurel J. Gabard-Durnam, Jessica E. Flannery, Bonnie Goff, Dylan G. Gee, Kathryn L. Humphreys, Eva H. Telzer, Todd A. Hare, Nim Tottenham. NeuroImage, 2014
359 citations recorded by the source corpus.
Functional connections (FC) between the amygdala and cortical and subcortical regions underlie a range of affective and cognitive processes. Despite the central role amygdala networks have in these functions, the normative developmental emergence of FC between the amygdala and the rest of the brain is still largely undefined. This study employed amygdala subregion maps and resting-state functional magnetic resonance imaging to characterize the typical development of human amygdala FC from age 4 to 23 years old (n = 58). Amygdala FC with subcortical and limbic regions was largely stable across this developmental period. However, three cortical regions exhibited age-dependent changes in FC: amygdala FC with the medial prefrontal cortex (mPFC) increased with age, while amygdala FC with a region including the insula and superior temporal sulcus decreased with age, and amygdala FC with a region encompassing the parahippocampal gyrus and posterior cingulate also decreased with age. The transition from childhood to adolescence (around age 10 years) marked an important change-point in the nature of amygdala-cortical FC. We distinguished unique developmental patterns of coupling for three amygdala subregions and found particularly robust convergence of FC for all subregions with the mPFC. These findings suggest that there are extensive changes in amygdala-cortical functional connectivity that emerge between childhood and adolescence.
Subfields: Cognitive Neuroscience, Experimental and Cognitive Psychology
View Paper: https://www.semanticscholar.org/paper/ecb8e0abd3aa388f1d99bc1c5a9e3531d3d53b92
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cognitive Neuroscience
- Alisa Powers
- B. Casey
- Gregory E. Miller
- Katie A. McLaughlin
- David G. Weissman
- Debbie Bitran
- Laurence Steinberg
- Rebecca M. Jones
In Experimental and Cognitive Psychology
Citations in the corpus
- The Adolescent Brain and the Emergence and Peak of Psychopathology (2015, background): “Studies of functional coupling between these cortical and subcortical regions show a developmental progression from late childhood to early adolescence (Gabard-Durnam et al., 2014).”
- Early-Life Adversity and Physical and Emotional Health across the Lifespan: A Neuro-Immune Network Hypothesis (2015, background): “Furthermore, prefrontal regulation of the amygdala typically emerges in adolescence (37,38).”
- Childhood Adversity and Neural Development: A Systematic Review (2019, background): “…development of this circuit has generally not been observed in resting-state studies (in which higher rs-fc reflects more mature development) (Gabard-Durnam et al. 2014) or studies examining the structure of uncinate fasciculus (in which higher FA reflects greater maturity) (Lebel et al.…”
- Distinct developmental changes in linear and nonlinear neural interactions across infancy and adulthood (2025, unknown): “…from infancy to adulthood is not yet well known, functional connectivity measures in infancy show increased complexity and e ffi ciency (Boersma et al., 2011; Cao et al., 2016; Damaraju et al., 2014) and a significant reorganisation in adolescence (Gabard-Durnam et al., 2014; Uhlhaas et al., 2009).”