A Single P450 Allele Associated with Insecticide Resistance in Drosophila

By P. Daborn, J. Yen, M. Bogwitz, G. L. Goff, E. Feil, S. Jeffers, N. Tijet, T. Perry, David G. Heckel, P. Batterham and 3 more. Science, 2002

841 citations recorded by the source corpus.

Subfields: Immunology, Insect Science, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/55abcad87b10f881830ba1cc9263324a4dc9535f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. M. Rockman
2. P. Hedrick

In Insect Science

1. René Feyereisen

In Molecular Biology

1. M. Berenbaum
2. M. Schuler
3. H. Ranson
4. Matthew W. Hahn
5. James P. Balhoff
6. Gregory A. Wray
7. D. Roelofs
8. René Feyereisen

Citations in the corpus

• Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism (2016, background): “It is worth to highlight that three P450 genes—Cyp6g1, Cyp6g2 and Cyp12d1—which are upregulated by CncC, are responsible for pesticide resistance in insects [34, 35].”
• Molecular mechanisms of metabolic resistance to synthetic and natural xenobiotics. (2007, background): “Cross-strain comparisons of the promoter sequences for the house fly genes CYP6D1 (104, 106) and CYP6D3 (63) as well as fruit fly genes CYP6A2 (31), CYP6A8 (80), CYP12A4 (12), and CYP6G1 (17, 25, 102) have been conducted to identify mutations and indels in cis-acting elements that might cause upregu”
• A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee (2006, background): “melanogaster, is part of a three gene cluster (Daborn et al., 2002).”
• INVITED REVIEW: Using genome scans of DNA polymorphism to infer adaptive population divergence (2005, background): “In some cases, such as the evolution of insecticide resistance in flies and mosquitoes (ffrench-Constant 1994; Raymond et al. 2001; Daborn et al. 2002) and drug resistance in malaria parasites Figure 2.”
• Molecular mechanisms of heavy metal tolerance and evolution in invertebrates (2009, background): “A transposon inserted in the promoter of the Cyp6gi (P450) gene increases the transcription of this gene and confers tolerance to DDT (Daborn et al., 2002).”
• The evolution of transcriptional regulation in eukaryotes. (2003, background): “Two other cases, mentioned earlier, are known from D. melanogaster : promoter alleles segregating at both Cyp6G1 and hsp70 appear to be under selection in wild populations (Daborn et al. 2002; Lerman et al. 2003).”