Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation

By E. Hirsch, V. Katanaev, C. Garlanda, O. Azzolino, L. Pirola, L. Silengo, S. Sozzani, A. Mantovani, F. Altruda, M. Wymann. 2000

1,203 citations recorded by the source corpus.

Subfields: Hematology, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/5570079d3b4759bbce815c99771c6caa83755cb2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. A. Mantovani
2. C. Garlanda

In Immunology

1. A. Mantovani
2. C. Garlanda
3. T. Kinashi
4. Erin R Green
5. G. T. Nguyen
6. J. Mecsas
7. K. Futosi
8. Szabina Fodor

In Oncology

1. C. Garlanda
2. A. Mantovani
3. A. Mócsai
4. C. Gerard
5. A. Sica
6. P. Allavena
7. F. Martínez
8. Lisa M. Coussens

Citations in the corpus

• Tumor suppressor PTEN mediates sensing of chemoattractant gradients. (2002, neutral): “(Hirsch et al., 2000; Li et al., 2000; Sasaki lian leukocytes have shown that chemoattractant recepet al., 2000).”
• PI3K pathway alterations in cancer: variations on a theme (2008, neutral): “Macrophages have matrix-remodeling capabilities that allow tumor cells to invade into the surrounding stroma and migrate toward blood vessels (Hirsch et al., 2000).”
• Chemotaxis: signalling the way forward (2004, background): “pl?O75747">PI3K γ as well as other class-I PI3Ks in neutrophil”
• Neutrophil cell surface receptors and their intracellular signal transduction pathways (2013, background): “On the other hand, PI3Kγwas not required for GPCR-induced Ca-signals [17,25,26] or fMLP-induced PKC activation [17].”
• Defective dendritic cell migration and activation of adaptive immunity in PI3Kγ‐deficient mice (2004, methodology): “The aim of the present work was to characterize the role of PI3Kg in DC recruitment in vitro and in vivo, using PI3Kg / mice (Hirsch et al, 2000).”
• Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow. (2000, background): “We show that by G protein-coupled receptors, has been functionally the chemokines SLC, ELC, and SDF-1a rapidly induce implicated in neutrophil migration (Hirsch et al., 2000).”
• Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance (2017, background): “In particular, it has been demonstrated that PI3Kγ, and more recently, PI3Kβ isoforms, are required for superoxide production (Hirsch et al., 2000; Li et al., 2000; Houslay, 2016).”