Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow.

By Gabriela Constantin, M. Majeed, C. Giagulli, L. Piccio, Ji Yun Kim, E. Butcher, C. Laudanna. Immunity, 2000

606 citations recorded by the source corpus.

Subfields: Immunology, Immunology and Allergy, Oncology

View Paper: https://www.semanticscholar.org/paper/1b9cf4331095354bc5f8a5ee37edff9d9faafed3

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In Immunology

1. J. Zindel
2. Carine Michiels
3. P. Kubes

In Immunology and Allergy

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In Oncology

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Citations in the corpus

• Endothelial cell functions (2003, background): “The stimulatory effects of chemokines (Constantin et al., 2000) and of PAF as well as signal transduction initiated by tethering L-selectin and PSGL-1 (McEver and Cummings, 1997; Simon et al., 1999; Williams and Solomkin, 1999) cause activation of leukocyte integrins which then bind to members of…”
• DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation. (2020, background): “Increased integrin binding (higher avidity) is the product of two events on a molecular level: first, a conformational change of individual integrin heterodimers (higher affinity) (39) and, second, an increased integrin density achieved by lateral mobility and increased expression (higher valency) (”