Psychosis prediction: 12-month follow up of a high-risk ("prodromal") group.

By A. Yung, Lisa J. Phillips, H. Yuen, S. Francey, Colleen A. McFarlane, M. Hallgren, Patrick D. McGorry. Schizophrenia Research, 2003

1,191 citations recorded by the source corpus.

Intervention in the prodromal phase of schizophrenia and related psychoses may result in attenuation, delay or even prevention of the onset of psychosis in some individuals. However, a "prodrome" is difficult to recognise prospectively because of its nonspecific symptoms. This study set out to recruit and follow up subjects at high risk of transition to psychosis with the aim of examining the predictive power for psychosis onset of certain mental state and illness variables.Symptomatic individuals with either a family history of psychotic disorder, schizotypal personality disorder, subthreshold psychotic symptoms or brief transient psychotic symptoms were assessed and followed up monthly for 12 months or until psychosis onset. Twenty of 49 subjects (40.8%) developed a psychotic disorder within 12 months. Some highly significant predictors of psychosis were found: long duration of prodromal symptoms, poor functioning at intake, low-grade psychotic symptoms, depression and disorganization. Combining some predictive variables yielded a strategy for psychosis prediction with good sensitivity (86%), specificity (91%) positive predictive value (80%) and negative predictive value (94%) within 6 months. This study illustrates that it is possible to recruit and follow up individuals at ultra high risk of developing psychosis within a relatively brief follow-up period. Despite low numbers some highly significant predictors of psychosis were found. The findings support the development of more specific preventive strategies targeting the prodromal phase for some individuals at ultra high risk of schizophrenia.

Subfields: Electrical and Electronic Engineering

View Paper: https://www.semanticscholar.org/paper/55569014dcbdb07b15bb4c63cc3b6ddd8dafb4e9

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Citations in the corpus

• The dopamine hypothesis of schizophrenia: version III--the final common pathway. (2009, positive): “Individuals meeting clinical criteria for a high risk of psychosis, eg, have an approximate 400-fold increased risk of developing of psychotic illnesses, predominantly schizophrenia, within the following few years.(115,116) They show elevated striatal [(18)F]-dopa accumulation, which is positively a”
• Dysconnectivity in schizophrenia: where are we now? (2011, background): “A relatively recent diagnostic category (Miller et al., 2002; Yung et al., 2003), the UHR/ARMS classification is one still very much in development, and to the best of the author’s knowledge, there is currently no publication to conclusively substantiate that the different diagnostic tools are asses”
• Mapping the Onset of Psychosis: The Comprehensive Assessment of At-Risk Mental States (2005, methodology): “In the original study [7], the one who”
• Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America. (2008, background): “Using empirically defined criteria for a high-risk clinical state that emphasize recent onset or worsening of subsyndromal psychotic symptoms,(9,10) previous studies have reported conversion rates of 9% to 76% in sample sizes of 13 to 110 subjects across 1- to 9-year follow-up intervals.(11-19) Much”
• Risk factors for psychosis in an ultra high-risk group: psychopathology and clinical features. (2004, background): “In a previous study (Yung et al., 2003), the ‘‘natural history’’ of the ARMS criteria was examined.”
• THE RELATIONSHIP OF SOCIAL ANXIETY AND SOCIAL ANHEDONIA TO PSYCHOMETRICALLY IDENTIFIED SCHIZOTYPY (2008, neutral): “However, the presence of depression and anxiety in premorbid or prodromal schizotypy appears to increase the risk of transition into psychosis (e.g., Yung et al., 2003).”
• Schizophrenia, "just the facts" 4. Clinical features and conceptualization. (2009, neutral): “sixth to one-half go on to develop schizophrenia depending on the population studied and criteria utilized (Yung et al., 2003; Cannon et al., 2008; Yung et al., 2008).”
• Predicting Psychosis: Meta-analysis of Transition Outcomes in Individuals at High Clinical Risk (2013, result): “One possible explanation is that more recent studies are recruiting individuals who would have made a transition to a psychotic disorder had it not been for the effect of clinical engagement.(75) We found some support for this hypothesis in the fact that transition risks were significantly lower in ”
• A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness–persistence–impairment model of psychotic disorder (2008, background): “…to as psychosis proneness, psychotic experiences, schizotypy or at-risk mental states (Meehl, 1962 ; Siever et al. 1993 ; Chapman et al. 1994 ; Claridge, 1997 ; Crow, 1998; Kwapil, 1998 ; Verdoux et al. 1998a ; van Os et al. 2000 ; Stefanis et al. 2002 ; Vollema et al. 2002; Yung et al. 2003).”
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• Can Paranoid Thoughts be Reduced by Targeting Negative Emotions and Self-Esteem? An Experimental Investigation of a Brief Compassion-Focused Intervention (2013, background): “4 the CAPE high scorers showed considerable variation in paranoia before and after the intervention and only few likely fulfilled the criteria that are used as a criterion in high-risk studies (Yung et al. 2003).”