Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro.

By Christie M. Sayes, F. Liang, Jared L. Hudson, Joe S Mendez, Wenh H. Guo, J. M. Beach, V. C. Moore, Condell D. Doyle, Jennifer L. West, W. Billups and 2 more. Toxicology Letters, 2006

844 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/5544fac243d480df8ef7c4fc6802db1c452d1ed2

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Citations in the corpus

A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice. (2008, background): “(SWNTs), with water-soluble, functionalized, pristine nanotubes being less cytotoxic than non-functionalized or oxidized tube”
Biomedical applications of functionalised carbon nanotubes. (2005, background): “Sayes et al. (2006) have shown that the level of cytotoxicity exerted by SWNTs is directly related to the density of functional groups around the tubes.”
Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. (2009, methodology): “Cell proliferation was estimated through mitochondrial activity (MTT assay).(46,47) Assays were done using SWNT cisplatin EGF and controls (cells only, cisplatin alone, and cisplatin-SWNT) using HN13 cells and those with EGFR knockdown siRNA or control siRNA without knockdown (Figure 4e).”
Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. (2007, background): “, indicating that a high degree of CNT functionalization leads to a dramatic reduction in toxic effect”
NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. (2009, background): “For example, some attempts to solubilise CNT through surface modification reported reduced toxicity as a result of the functionalisation [163,177].”
An Overview of the Recent Progress in the Synthesis and Applications of Carbon Nanotubes (2019, background): “In vitro studies have indicated that the intrinsic toxicity of SWCNT, functionalized by phenyl–SO3H or phenyl–(COOH)2 groups by a covalent method decreases the cytotoxic effects [120].”
Carbon nanotubes as nanomedicines: from toxicology to pharmacology. (2006, background): “Concerning the intrinsic toxicity of CNT, in vitro studies had indicated that SWNT functionalised by a covalent method with phenyl-SO3H or phenyl-(COOH)2 groups produced less cytotoxic effects than aqueous dispersions of pristine SWNT stabilised with a surfactant — 1% of Pluronic F108 [8].”
Nanoparticles as drug delivery systems (2012, background): “Incubation of bronchial epithelial cells and keratinocytes with high doses of SWCNT resulted in oxidative stress, including ROS generation, lipid peroxidation and mitochondrial dysfunction [133].”
Carbon Nanotubes in Biology and Medicine: In vitro and in vivo Detection, Imaging and Drug Delivery (2009, background): “the toxicity of CNTs was dependent on the density of functionalization on nanotubes, with minimal toxicity for those heavily functionalized with the highest density of phenyl-SO3X groups on nanotubes [112]. These results are understandable because CNTs without proper functionalization have a highly ”