Prognostic significance of the tumor-stroma ratio: validation study in node-negative premenopausal breast cancer patients from the EORTC perioperative chemotherapy (POP) trial (10854)

By T. Dekker, C. V. D. Velde, G. V. Pelt, J. Kroep, J. Julien, V. Smit, R. Tollenaar, W. Mesker. 2013

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Discrimination between tumour epithelium and stroma via perception-based features (2015, background): “In particular, we assess the capability of the following five visual features to correctly discriminate epithelium from stroma in digitised tissue micro-arrays of colorectal cancer: oarseness, contrast, directionality, line-likeliness and roughness.”
The prognostic significance of tumour–stroma ratio in oestrogen receptor-positive breast cancer (2014, methodology): “Dekker et al (2013) used a compass system to ensure only areas that were surrounded by tumour cells in all directions, were sampled and avoided peripheral regions.”