MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1

By T. A. Harris, M. Yamakuchi, M. Ferlito, Joshua T. Mendell, C. Lowenstein. Proceedings of the National Academy of Sciences of the United States of America, 2008

1,025 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/54b3d4664aee17670213593c22e1242fd82b0523

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In Cancer Research

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Citations in the corpus

• An Analysis of Human MicroRNA and Disease Associations (2008, result): “MiR126 has the highest expression in cardiovascular tissues in our analysis and was reported has high heart specificity[25], and therefore was predicted to be associated with cardiovascular disease and validated by later research[26], in which Harris et al.”
• An Endothelial-specific microRNA Governs Vascular Integrity and Angiogenesis (2008, background): “…showed miR-126 to be expressed in a broad range of tissues, with highest expression in lung and heart (Figure 1A) consistent with prior studies (Harris et al., 2008; Lagos-Quintana et al., 2002; Musiyenko et al., 2008). miR-126* was detectable at only trace levels of expression (data not…”
• Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies (2021, background): “B. Inflammation Vascular inflammation plays an important role in the initiation and progression of atherosclerosis and other forms of CVD (Haybar et al., 2019) (Figs.”
• MicroRNAs in development and disease. (2011, background): “It is also highly expressed in murine lung and heart and to a lesser extent in the brain, liver, and kidney, where it is localized to endothelial (235) and epithelial cells (222).”
• Role of microRNAs in vascular diseases, inflammation, and angiogenesis. (2008, background): “Thus, decreasing miR-126 in endothelial cells increases TNFa-stimulated VCAM-1 expression and enhances leukocyte adherence to endothelial cells.(63) Recently, it has been shown that miR-21 is a regulator of neointima lesion formation(36) (Table 1).”
• Pervasive roles of microRNAs in cardiovascular biology (2011, background): “miR-126 may also influence susceptibility to atherosclerosis, through the modification of endothelial cell functio”
• Atherosclerosis: current pathogenesis and therapeutic options (2011, background): “Thus, local CXCL12 induction conferred by miR-126 in endothelial apoptotic bodies may pomote atheroprotection, which can be enhanced by miR-126–mediated repression of endothelial vascular cell adhesion molecule-1 expressio”
• miRBase: annotating high confidence microRNAs using deep sequencing data (2013, background): “However, this microRNA otherwise shows the correct processing pattern, and has been extensively studied (17).”